| + |
BRK1 | up-regulates activity 
binding
|
NHS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
We show that the WHD of NHS interacts with the Abi family of proteins, HSPC300, Nap1 and Sra1, and is important for the localization of NHS to the leading edge. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHS | up-regulates activity
relocalization
|
WRC complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
Excessive cell spreading and lamellipod extension as a result of NHS knockdown is likely to be a result of loss of WAVE complex regulation, leading to overactive WAVE activity or a dysregulation of nascent focal adhesions in lamellipodia.WAVE and NHS protein partners Abi1 and HSPC300, and the p34 subunit of the Arp2/3 complex, consistently localized at the edges of cells treated with NHS siRNA, independent of EGF stimulation and WAVE complex activation. These data show that localization of Abi1 and HSPC300 was altered in the absence of NHS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHS | up-regulates 
|
Actin_cytoskeleton_reorganization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
We demonstrate that NHS is essential for maintaining cell morphology through the regulation of actin cytoskeletal dynamics and suggest that an important mechanism of remodelling of the actin cytoskeleton during development would therefore be lost in patients with NHS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TJP1 | up-regulates activity
binding
|
NHS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253567 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19447104 |
NHS-A is a novel interactor of ZO-1 and is expected to have a role at tight junctions. Its recruitment to these junctions is dependent upon their assembly. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NHS | up-regulates activity
binding
|
ABI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
NHS may preferentially bind one or more Abi's in vivo, and it is also likely that specificity is governed by spatiotemporal expression of both proteins. Abi2 is highly expressed in the lens and plays a pivotal role in the development of the anterior and posterior sutures. This suggests that an NHS–Abi2 interaction may be physiologically important for lens development and that null mutations in the NHS gene could cause congenital cataract by disruption of this interaction and the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lens |
| + |
CYFIP1 | up-regulates activity
binding
|
NHS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
We show that the WHD of NHS interacts with the Abi family of proteins, HSPC300, Nap1 and Sra1, and is important for the localization of NHS to the leading edge. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHS | up-regulates activity
relocalization
|
ARP2/3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
NHS knockdown also resulted in the mislocalization of the Arp2/3 complex and disruption of the actin cytoskeleton. in the absence of NHS, Arp2/3 localization and F-actin distribution are disrupted, suggesting that Arp2/3 actin-nucleation activity is mediated, in part, by NHS providing an additional functional link between NHS and actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCKAP1 | up-regulates activity
binding
|
NHS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253576 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
We show that the WHD of NHS interacts with the Abi family of proteins, HSPC300, Nap1 and Sra1, and is important for the localization of NHS to the leading edge. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NHS
- 
- 