| + |
DLX2 | up-regulates quantity by expression 
transcriptional regulation
|
ARX |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251972 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18923043 |
Dlx overexpression induces ectopic expression of endogenous Arx and its isolated enhancer, whereas loss of Dlx expression results in reduced Arx expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSX1 | down-regulates activity 
binding
|
DLX2 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240929 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 9111364 |
We demonstrate that dimerization by Msx and Dlx proteins is mediated through their homeodomains and that the residues required for this interaction correspond to those necessary for DNA binding. Unlike most other known examples of homeoprotein interactions, association of Msx and Dlx proteins does not promote cooperative DNA binding; instead, dimerization and DNA binding are mutually exclusive activities. Msx proteins act as transcriptional repressors and Dlx proteins act as activators, while in combination, Msx and Dlx proteins counteract each other's transcriptional activities. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MSX2 | down-regulates activity
binding
|
DLX2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240932 |
|
|
Mus musculus |
CAL-51 Cell |
| pmid |
sentence |
| 9111364 |
We demonstrate that dimerization by Msx and Dlx proteins is mediated through their homeodomains and that the residues required for this interaction correspond to those necessary for DNA binding. Unlike most other known examples of homeoprotein interactions, association of Msx and Dlx proteins does not promote cooperative DNA binding; instead, dimerization and DNA binding are mutually exclusive activities. Msx proteins act as transcriptional repressors and Dlx proteins act as activators, while in combination, Msx and Dlx proteins counteract each other's transcriptional activities. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DLX2 | down-regulates activity
binding
|
MSX2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240911 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9111364 |
We demonstrate that dimerization by Msx and Dlx proteins is mediated through their homeodomains and that the residues required for this interaction correspond to those necessary for DNA binding. Unlike most other known examples of homeoprotein interactions, association of Msx and Dlx proteins does not promote cooperative DNA binding; instead, dimerization and DNA binding are mutually exclusive activities. Msx proteins act as transcriptional repressors and Dlx proteins act as activators, while in combination, Msx and Dlx proteins counteract each other's transcriptional activities. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DLX2 | down-regulates activity
binding
|
MSX1 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240918 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 9111364 |
We demonstrate that dimerization by Msx and Dlx proteins is mediated through their homeodomains and that the residues required for this interaction correspond to those necessary for DNA binding. Unlike most other known examples of homeoprotein interactions, association of Msx and Dlx proteins does not promote cooperative DNA binding; instead, dimerization and DNA binding are mutually exclusive activities. Msx proteins act as transcriptional repressors and Dlx proteins act as activators, while in combination, Msx and Dlx proteins counteract each other's transcriptional activities. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
DLX2
- 
- 