+ |
PRKCA | up-regulates activity
phosphorylation
|
ARX |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277418 |
Ser174 |
VSISRSKsYRENGAP |
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
30419043 |
We confirm that ARX is phosphorylated by PRKCA and demonstrate phosphorylation at serine 174. We demonstrate that phosphorylation is required for correct transcriptional activity of the ARX protein using transcriptome-wide analysis of gene expression of phospho-null mutants (alanines replacing serines) compared to ARX wild-type (ARX-WT) overexpressed in pancreatic alpha TC cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DLX2 | up-regulates quantity by expression
transcriptional regulation
|
ARX |
0.278 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251972 |
|
|
Homo sapiens |
|
pmid |
sentence |
18923043 |
Dlx overexpression induces ectopic expression of endogenous Arx and its isolated enhancer, whereas loss of Dlx expression results in reduced Arx expression |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ARX | down-regulates quantity by repression
transcriptional regulation
|
EBF3 |
0.309 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251971 |
|
|
Homo sapiens |
|
pmid |
sentence |
19627984 |
Arx is sufficient to repress Ebf3 endogenous expression and that its silencing in Arx mutant tissues partially rescues tangential cell movement. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |