| + |
PKA | up-regulates activity 
phosphorylation
|
PDE4C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275987 |
Ser14 |
GEGAEACsRLSRSRG |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12023945 |
Phosphorylation of long PDE4 isoforms by PKA. COS1 cells were transfected to express various long PDE4 isoforms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273938 |
Ser14 |
GEGAEACsRLSRSRG |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12023945 |
Long PDE4 isoforms from all four sub-families can be phosphorylated by protein kinase A (PKA). This leads to an increase in their activity and may thus contribute to cellular desensitization processes in cells where these isoforms are selectively expressed.These were Ser89Ala-PDE4A8, Ser133Ala-PDE4B1, Ser13Ala-PDE4C2 and Ser126Ala-PDE4D5. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
MAPK1 | down-regulates 
phosphorylation
|
PDE4C |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83187 |
Ser641 |
YQSKIPRsPSDLTNP |
Homo sapiens |
|
| pmid |
sentence |
| 11030732 |
The short-form pde4b2 isoenzyme was activated by erk2 phosphorylation. sub-family selective actions in the ability of erk2 map kinase to phosphorylate and regulate the activity of pde4 cyclic amp-specific phosphodiesterases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PDE4C
- 
- 