3.0
Summary
| Name |  FCHO2
|
| Full Name | F-BAR domain only protein 2 |
| Synonyms | FCHO2_HUMAN | |
| Primary ID | Q0JRZ9 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FCHO2 | up-regulates quantity by stabilization 
binding
|
AP-2/clathrin vescicle | 0.558 |
| Publications: | 1 | |||