| + |
AP-2/clathrin vescicle | up-regulates 
|
Endocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260705 |
|
|
|
|
| pmid |
sentence |
| 24130457 |
AP-2 is the core-organizing element in clathrin-mediated endocytosis. During the formation of clathrin-coated vesicles, clathrin and endocytic accessory proteins interact with AP-2 in a temporally and spatially controlled manner |
|
| Publications: |
1 |
| + |
CLTB | form complex 
binding
|
AP-2/clathrin vescicle |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLTA | form complex
binding
|
AP-2/clathrin vescicle |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCHO2 | up-regulates quantity by stabilization 
binding
|
AP-2/clathrin vescicle |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260717 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Early recruitment of FCHo1/2, Eps15, epsin, and intersectin to the rims of assembling coated pits is essential for their stability and further growth |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates
|
AP-2/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | form complex
binding
|
AP-2/clathrin vescicle |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HSPA8 | down-regulates quantity by destabilization 
binding
|
AP-2/clathrin vescicle |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260718 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Hsc70, recruited by the J-domain protein auxilin, mediates clathrin uncoating and release of a free vesicle, primed to fuse with a target membrane. |
|
| Publications: |
1 |
| + |
DAMPS | up-regulates
|
AP-2/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AP-2/clathrin vescicle | up-regulates
|
Receptor_mediated_ endocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260704 |
|
|
|
|
| pmid |
sentence |
| 17522231 |
These results suggest that when SARS-CoV binds ACE2 it is internalized and penetrates early endosomes in a clathrin-dependent manner |The clathrin-dependent endocytosis is initiated by the binding of adaptor protein 2 (AP2) complexes to the cytoplasmic tail of the cell-surface receptors, which recruits clathrins |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
EPN1 | up-regulates quantity by stabilization
binding
|
AP-2/clathrin vescicle |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260716 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Early recruitment of FCHo1/2, Eps15, epsin, and intersectin to the rims of assembling coated pits is essential for their stability and further growth |
|
| Publications: |
1 |
| + |
CLTCL1 | form complex
binding
|
AP-2/clathrin vescicle |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLTC | form complex
binding
|
AP-2/clathrin vescicle |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITSN1 | up-regulates quantity by stabilization
binding
|
AP-2/clathrin vescicle |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260714 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Early recruitment of FCHo1/2, Eps15, epsin, and intersectin to the rims of assembling coated pits is essential for their stability and further growth |
|
| Publications: |
1 |
| + |
FCHO1 | up-regulates quantity by stabilization
binding
|
AP-2/clathrin vescicle |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260715 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Early recruitment of FCHo1/2, Eps15, epsin, and intersectin to the rims of assembling coated pits is essential for their stability and further growth |
|
| Publications: |
1 |
| + |
EPS15 | up-regulates quantity by stabilization
binding
|
AP-2/clathrin vescicle |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260713 |
|
|
|
|
| pmid |
sentence |
| 24789820 |
Early recruitment of FCHo1/2, Eps15, epsin, and intersectin to the rims of assembling coated pits is essential for their stability and further growth |
|
| Publications: |
1 |
| + |
Spike protein-ACE2 | up-regulates
|
AP-2/clathrin vescicle |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260711 |
|
|
|
|
| pmid |
sentence |
| 17522231 |
These results suggest that when SARS-CoV binds ACE2 it is internalized and penetrates early endosomes in a clathrin-dependent manner |The clathrin-dependent endocytosis is initiated by the binding of adaptor protein 2 (AP2) complexes to the cytoplasmic tail of the cell-surface receptors, which recruits clathrins |
|
| Publications: |
1 |
| Pathways: | SARS-CoV ATTACHMENT AND ENTRY |
| + |
CoV2 Spike protein-ACE2 | up-regulates
|
AP-2/clathrin vescicle |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260756 |
|
|
|
|
| pmid |
sentence |
| 17522231 |
These results suggest that when SARS-CoV binds ACE2 it is internalized and penetrates early endosomes in a clathrin-dependent manner |The clathrin-dependent endocytosis is initiated by the binding of adaptor protein 2 (AP2) complexes to the cytoplasmic tail of the cell-surface receptors, which recruits clathrins |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
AP-2 complex | form complex
binding
|
AP-2/clathrin vescicle |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AP-2/clathrin vescicle | up-regulates quantity
relocalization
|
oligopeptide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs cell surface receptors facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. It is in these compartments that internalized antigen proteolysis and peptide–MHC class II complex formation takes place. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
AP-2/clathrin vescicle
SIGNOR-C245