Summary

Name ARHGEF5
Full Name Rho guanine nucleotide exchange factor 5
Synonyms Ephexin-3, Guanine nucleotide regulatory protein TIM, Oncogene TIM, Transforming immortalized mammary oncogene, p60 TIM | TIM
Primary ID Q12774
Links - -
Type protein
Relations 1
Function Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ARHGEF5up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.6
Publications: 1 Organism: Homo Sapiens