Summary

Name SMARCB1
Full Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Synonyms BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, hSNF5 | BAF47, INI1, SNF5L1
Primary ID Q12824
Links - -
Type protein
Relations 8
Function Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding SWI/SNF complex 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMARCB1 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png E2F1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CCNA2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CDC6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CSF1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMARCB1 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CCNA1 0.14
Publications: 1 Organism: Homo Sapiens