| + |
CDK2 | up-regulates 
phosphorylation
|
CDC6 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67540 |
Ser106 |
DNQLTIKsPSKRELA |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Based on these results, we propose that phosphorylation of hscdc6 by cdks regulates dna replication of at least two steps: first, by promoting initiation of dna replication and, second, through nuclear exclusion preventing dna rereplication. hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | up-regulates
phosphorylation
|
CDC6 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217272 |
Ser106 |
DNQLTIKsPSKRELA |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Based on these results, we propose that phosphorylation of hscdc6 by cdks regulates dna replication of at least two steps: first, by promoting initiation of dna replication and, second, through nuclear exclusion preventing dna rereplication. hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates activity 
phosphorylation
|
CDC6 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63891 |
Ser54 |
RVKALPLsPRKRLGD |
Homo sapiens |
|
| pmid |
sentence |
| 9889196 |
Phosphorylation of mammalian cdc6 by cyclin a/cdk2 regulates its subcellular localization/based on our data we suggest that the phosphorylation of cdc6 by cyclin a/cdk2 is a negative regulatory event that could be implicated in preventing re-replication during s phase and g2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67544 |
Ser54 |
RVKALPLsPRKRLGD |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106)|An HsCdc6A1A2A3 mutant, which mimics unphosphorylated HsCdc6, is exclusively nuclear, and its expression inhibits initiation of DNA replication. An HsCdc6E1E2E3 mutant, which mimics phosphorylated HsCdc6, is exclusively cytoplasmic and is not associated with the chromatin/nuclear matrix fraction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63895 |
Ser74 |
TPHLPPCsPPKQGKK |
Homo sapiens |
|
| pmid |
sentence |
| 9889196 |
Phosphorylation of mammalian cdc6 by cyclin a/cdk2 regulates its subcellular localization/based on our data we suggest that the phosphorylation of cdc6 by cyclin a/cdk2 is a negative regulatory event that could be implicated in preventing re-replication during s phase and g2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67548 |
Ser74 |
TPHLPPCsPPKQGKK |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106)|An HsCdc6A1A2A3 mutant, which mimics unphosphorylated HsCdc6, is exclusively nuclear, and its expression inhibits initiation of DNA replication. An HsCdc6E1E2E3 mutant, which mimics phosphorylated HsCdc6, is exclusively cytoplasmic and is not associated with the chromatin/nuclear matrix fraction. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | down-regulates activity
phosphorylation
|
CDC6 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217328 |
Ser54 |
RVKALPLsPRKRLGD |
Homo sapiens |
|
| pmid |
sentence |
| 9889196 |
Phosphorylation of mammalian cdc6 by cyclin a/cdk2 regulates its subcellular localization/based on our data we suggest that the phosphorylation of cdc6 by cyclin a/cdk2 is a negative regulatory event that could be implicated in preventing re-replication during s phase and g2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217276 |
Ser54 |
RVKALPLsPRKRLGD |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106)|An HsCdc6A1A2A3 mutant, which mimics unphosphorylated HsCdc6, is exclusively nuclear, and its expression inhibits initiation of DNA replication. An HsCdc6E1E2E3 mutant, which mimics phosphorylated HsCdc6, is exclusively cytoplasmic and is not associated with the chromatin/nuclear matrix fraction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217332 |
Ser74 |
TPHLPPCsPPKQGKK |
Homo sapiens |
|
| pmid |
sentence |
| 9889196 |
Phosphorylation of mammalian cdc6 by cyclin a/cdk2 regulates its subcellular localization/based on our data we suggest that the phosphorylation of cdc6 by cyclin a/cdk2 is a negative regulatory event that could be implicated in preventing re-replication during s phase and g2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217280 |
Ser74 |
TPHLPPCsPPKQGKK |
Homo sapiens |
|
| pmid |
sentence |
| 10339564 |
Hscdc6 is an excellent substrate for cdk2 in vitro and is phosphorylated in vivo at three sites (ser-54, ser-74, and ser-106)|An HsCdc6A1A2A3 mutant, which mimics unphosphorylated HsCdc6, is exclusively nuclear, and its expression inhibits initiation of DNA replication. An HsCdc6E1E2E3 mutant, which mimics phosphorylated HsCdc6, is exclusively cytoplasmic and is not associated with the chromatin/nuclear matrix fraction. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
CDC6 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169184 |
Thr37 |
SDAKLEPtNVQTVTC |
Homo sapiens |
|
| pmid |
sentence |
| 21041660 |
Binding between cdc6 and plk1 occurs through the polo-box domain of plk1, and cdc6 is phosphorylated by plk1 on t37. These results suggest that plk1-mediated phosphorylation of cdc6 promotes the interaction of cdc6 and cdk1, leading to the attenuation of cdk1 activity, release of separase, and subsequent anaphase progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
CDC6 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276564 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
APC-c | up-regulates activity
binding
|
CDC6 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271386 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10995389 |
Furthermore, APC, in association with CDH1, ubiquitinates CDC6 in vitro, and both APC and CDH1 are required and limiting for CDC6 proteolysis in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates quantity by expression
transcriptional regulation
|
CDC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276576 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| + |
SMARCB1 | down-regulates 
|
CDC6 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92785 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12226744 |
We show that the ectopic expression of wild-type hsnf5/ini1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into s phase of mrt cells. This g1 arrest is associated with down-regulation of a subset of e2f targets including cyclin a, e2f1 and cdc6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDC6
- 
- 