Relation Results

Summary

Name SMARCB1
Full Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Synonyms BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, hSNF5 | BAF47, INI1, SNF5L1
Primary ID Q12824
Links - -
Type protein
Relations 18
Function Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differen ...
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Type: Score: Layout: SPV 
0.7570.3420.20.3180.830.8530.8330.8950.9420.8140.9220.2490.3210.3510.850.8440.8510.863SMARCB1Embryonic stem cell-specific SWI/SNFCCNA1CSF1CDC6Brain-specific SWI/SNF SMARCA2 variantNeural progenitor-specific SWI/SNFBrain-specific SWI/SNF SMARCA4 variantSWI/SNF complexSMARCA4SWI/SNF ACTL6B varianSMARCA2E2F1CHFRCCNA2Muscle cell-specific SWI/SNF ARID1B variantMuscle cell-specific SWI/SNF SMARCA4 variantMuscle cell-specific SWI/SNF ARID1A variantSWI/SNF ACTL6A-ARID1A-SMARCA2 variant

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Relations
Regulator
Mechanism
target
score ℹ
+ SMARCB1form complex img/form-complex.png binding Embryonic stem cell-specific SWI/SNF 0.757
Identifier Residue Sequence Organism Cell Line
SIGNOR-270725 Mus musculus Embryonic Stem Cell
pmid sentence
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
Publications: 1 Organism: Mus Musculus
+ SMARCB1down-regulates img/indirect_inhibition.png CCNA1 0.342
Identifier Residue Sequence Organism Cell Line
SIGNOR-92779 Homo sapiens
pmid sentence
We show that the ectopic expression of wild-type hsnf5/ini1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into s phase of mrt cells. This g1 arrest is associated with down-regulation of a subset of e2f targets including cyclin a, e2f1 and cdc6.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CSF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-141047 Homo sapiens HeLa Cell
pmid sentence
Ini1/hsnf5/baf47 is involved in activation of the csf1 promoter.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1down-regulates img/indirect_inhibition.png CDC6 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-92785 Homo sapiens
pmid sentence
We show that the ectopic expression of wild-type hsnf5/ini1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into s phase of mrt cells. This g1 arrest is associated with down-regulation of a subset of e2f targets including cyclin a, e2f1 and cdc6.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1form complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA2 variant 0.83
Identifier Residue Sequence Organism Cell Line
SIGNOR-270747 Homo sapiens
pmid sentence
 Whereas chromatin-remodeling complexes are generally thought to promote gene expression, recent genetic and biochemical studies suggest that the SWI/SNF complex may also be involved in transcriptional repression . The subunit composition of the different human complexes that belong to this family is listed in Table 1. Several of the subunits, including SNF5/INI1, are common to all complexes and may constitute its core.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ SMARCB1form complex img/form-complex.png binding Neural progenitor-specific SWI/SNF 0.853
Identifier Residue Sequence Organism Cell Line
SIGNOR-270618 Homo sapiens
pmid sentence
The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. 
Publications: 1 Organism: Homo Sapiens
+ SMARCB1form complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA4 variant 0.833
Identifier Residue Sequence Organism Cell Line
SIGNOR-270755 Homo sapiens
pmid sentence
 Whereas chromatin-remodeling complexes are generally thought to promote gene expression, recent genetic and biochemical studies suggest that the SWI/SNF complex may also be involved in transcriptional repression . The subunit composition of the different human complexes that belong to this family is listed in Table 1. Several of the subunits, including SNF5/INI1, are common to all complexes and may constitute its core.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ SMARCB1form complex img/form-complex.png binding SWI/SNF complex 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-132930 Homo sapiens
pmid sentence
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1up-regulates activity img/direct-activation.png binding SMARCA4 0.942
Identifier Residue Sequence Organism Cell Line
SIGNOR-65438 Homo sapiens
pmid sentence
The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1form complex img/form-complex.png binding SWI/SNF ACTL6B varian 0.814
Identifier Residue Sequence Organism Cell Line
SIGNOR-270607 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 1 Organism: Homo Sapiens
+ SMARCB1up-regulates activity img/direct-activation.png binding SMARCA2 0.922
Identifier Residue Sequence Organism Cell Line
SIGNOR-65181 Homo sapiens
pmid sentence
The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1down-regulates img/indirect_inhibition.png E2F1 0.249
Identifier Residue Sequence Organism Cell Line
SIGNOR-92788 Homo sapiens
pmid sentence
We show that the ectopic expression of wild-type hsnf5/ini1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into s phase of mrt cells. This g1 arrest is associated with down-regulation of a subset of e2f targets including cyclin a, e2f1 and cdc6.
Publications: 1 Organism: Homo Sapiens
+ CHFRdown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SMARCB1 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-271458 Chlorocebus aethiops COS-7 Cell
pmid sentence
Here we report that CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway, and that SRG3/mBAF155 stabilizes these components by blocking their interaction with CHFR. These results suggest that CHFR enhances the degradation of the components of the SWI/SNF-like BAF complex by inducing their poly-ubiquitination.
Publications: 1 Organism: Chlorocebus Aethiops
+ SMARCB1down-regulates img/indirect_inhibition.png CCNA2 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-92782 Homo sapiens
pmid sentence
We show that the ectopic expression of wild-type hsnf5/ini1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into s phase of mrt cells. This g1 arrest is associated with down-regulation of a subset of e2f targets including cyclin a, e2f1 and cdc6.
Publications: 1 Organism: Homo Sapiens
+ SMARCB1form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1B variant 0.85
Identifier Residue Sequence Organism Cell Line
SIGNOR-270710 Homo sapiens
pmid sentence
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain access to targets in chromatin. Our data suggest that BAF250 confers specificity to the human BAF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMARCB1form complex img/form-complex.png binding Muscle cell-specific SWI/SNF SMARCA4 variant 0.844
Identifier Residue Sequence Organism Cell Line
SIGNOR-270737 Homo sapiens
pmid sentence
We have also found that, of the two human SWI/2/SNF2 family-related ATPases, the PBAF complex contains only BRG1 but not hbrm (Xue et al., submitted). In contrast, the BAF complex isolated by BAF250 can include either BRG1 or hbrm (Fig. ​(Fig.4b).4b). These data underscore the distinctness of the two human complexes and suggest that BAF250 is a signature subunit that may confer specificity to the BAF complex.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMARCB1form complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1A variant 0.851
Identifier Residue Sequence Organism Cell Line
SIGNOR-270697 Homo sapiens
pmid sentence
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain access to targets in chromatin. Our data suggest that BAF250 confers specificity to the human BAF complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ SMARCB1form complex img/form-complex.png binding SWI/SNF ACTL6A-ARID1A-SMARCA2 variant 0.863
Identifier Residue Sequence Organism Cell Line
SIGNOR-269825 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 1 Organism: Homo Sapiens
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