Relation Results

Summary

Name KIF5A
Full Name Kinesin heavy chain isoform 5A
Synonyms Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC | NKHC1
Primary ID Q12840
Links - -
Type protein
Relations 3
Function Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like memb ...
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Type: Score: Layout: SPV 
0.70.3150.7KIF5AOrganelle_transportDLG4Plus-end directed sliding movement

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Relations
Regulator
Mechanism
target
score ℹ
+ KIF5Aup-regulates img/indirect-activation.png Organelle_transport 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264067 Homo sapiens Neuron
pmid sentence
The kinesin superfamily of proteins plays a major role in this complex organelle transport. Kinesin is primarily associated with anterogradely transported membranous organelles in nerve axons. KIF5B and HsuKHC are expressed ubiquitously in many tissues, whereas KIF5A, KIF5C, and HsnKHC are specific to nerve tissue.
Publications: 1 Organism: Homo Sapiens
+ KIF5Aup-regulates activity img/direct-activation.png binding DLG4 0.315
Identifier Residue Sequence Organism Cell Line
SIGNOR-264065 Homo sapiens
pmid sentence
Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions
Publications: 1 Organism: Homo Sapiens
+ KIF5Aup-regulates img/indirect-activation.png Plus-end directed sliding movement 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-272523 Homo sapiens
pmid sentence
In general, N-kinesins and C-kinesins drive microtubule plus end- and minus end-directed motilities, respectively, and M-kinesins depolymerize microtubules1,9 (Box 1).|Forty-five genes that encode kinesin superfamily proteins (also known as KIFs) have been discovered in the mouse and human genomes.|KIFs are molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs, along the microtubule system.
Publications: 1 Organism: Homo Sapiens
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