Summary

Name DLG4
Full Name Disks large homolog 4
Synonyms Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90 | PSD95
Primary ID P78352
Links - -
Type protein
Relations 45
Pathways Glutamatergic synapse
Function Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png palmitoylation DLG4 0.394
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.588
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.585
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding DLG4 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.729
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TANC1 0.621
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding DLG4 0.93
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png binding DLG4 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png binding DLG4 0.792
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOS1 0.725
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.671
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.801
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.377
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png post transcriptional regulation DLG4 0.493
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates quantity img/direct-activation.png post transcriptional regulation DLG4 0.275
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates quantity img/direct-activation.png binding DLG4 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding DLG4 0.737
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.768
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ form complex img/form-complex.png binding Scribble_complex_DLG4-LLGL2_variant 0.45
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Scribble_complex_DLG4-LLGL1_variant 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.747
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TANC2 0.318
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding LRFN2 0.74
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.466
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png binding DLG4 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.384
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding DLG4 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png relocalization DLGAP1 0.93
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png relocalization GRIN2B 0.818
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GRIN2A 0.805
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Postsynaptic density assembly 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.745
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.746
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DLG4 0.689
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization DLG4 0.49
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding DLG4 0.794
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRFN1 0.767
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DLG4 0.361
Publications: 1 Organism: Homo Sapiens