| + |
MAP2K7 | down-regulates activity 
phosphorylation
|
FADD |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123164 |
Ser194 |
QNRSGAMsPMSWNSD |
Homo sapiens |
|
| pmid |
sentence |
| 15001534 |
The results clearly show that fadd phosphorylation at ser194 affects functions both upstream and downstream of the mekk1/mkk7/jnk1 pathway and is closely associated with chemosensitivity in prostate cancer cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling |
| + |
MAP3K1 | up-regulates 
phosphorylation
|
MAP2K7 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51207 |
Ser271 |
ISGRLVDsKAKTRSA |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Here we show that jnkk2, a novel member of the map kinase kinase family, was phosphorylated and activated by mekk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51211 |
Thr275 |
LVDSKAKtRSAGCAA |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Here we show that jnkk2, a novel member of the map kinase kinase family, was phosphorylated and activated by mekk1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors |
| + |
MAP2K7 | down-regulates activity
phosphorylation
|
IRS1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217920 |
Ser312 |
TESITATsPASMVGG |
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signalInsulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 Ser312 can be phosphorylated by kinases, such as c-jun NH2-terminal kinase and inhibitor of _B kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
MAPK9 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251416 |
Ser407 |
STEQTLAsDTDSSLD |
in vitro |
|
| pmid |
sentence |
| 11062067 |
MKK7 also phosphorylates JNK2 alpha 2 at Thr-404 and Ser-407 in vitro. Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251417 |
Thr183 |
ACTNFMMtPYVVTRY |
in vitro |
|
| pmid |
sentence |
| 11062067 |
MKK7 phosphorylates SAPK2a p38 exclusively at Tyr-182. Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251418 |
Thr404 |
SSMSTEQtLASDTDS |
in vitro |
|
| pmid |
sentence |
| 11062067 |
MKK7 also phosphorylates JNK2 alpha 2 at Thr-404 and Ser-407 in vitro. Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
MAPK13 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273954 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273953 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K7 | up-regulates
phosphorylation
|
MAPK9 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83744 |
Thr183 |
ACTNFMMtPYVVTRY |
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). These results indicate that hgk, a novel activator of the jnk pathway, may function through tak1, and that the hgk --> tak1 --> mkk4, mkk7 --> jnk kinase cascade may mediate the TNF-alphalpha signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63976 |
Thr183 |
ACTNFMMtPYVVTRY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9890973 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1). These results indicate that hgk, a novel activator of the jnk pathway, may function through tak1, and that the hgk --> tak1 --> mkk4, mkk7 --> jnk kinase cascade may mediate the TNF-alphalpha signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83748 |
Tyr185 |
TNFMMTPyVVTRYYR |
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
In the present study, we found that mkk7 phosphorylates sapk2a/p38 exclusively at tyr-182, albeit at a low rate. Therefore one possibility is that the interaction of mkk7 and/or sapk1/jnk with another cellular protein alters the conformation of one of these enzymes in such a way as to facilitate phosphorylation of tyr-185 by mkk7 in vivo. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAP2K7 | up-regulates
phosphorylation
|
MAPK8 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83736 |
Thr183 |
AGTSFMMtPYVVTRY |
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Jnk full activation requires the phosphorylation of a threonine and a tyrosine residue in a thr-pro-tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (mkk)4 and mkk7. Mkk7 shows a striking preference for the threonine residue (thr-183). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51199 |
Thr183 |
AGTSFMMtPYVVTRY |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Jnk is activated by jnk-activating kinase 1 (jnkk1), a dual specificity protein kinase that phosphorylates jnk on threonine 183 and tyrosine 185 residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51203 |
Tyr185 |
TSFMMTPyVVTRYYR |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Jnk is activated by jnk-activating kinase 1 (jnkk1), a dual specificity protein kinase that phosphorylates jnk on threonine 183 and tyrosine 185 residues. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, TNF-alpha Signaling, Toll like receptors |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
MAPK10 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251422 |
Thr221 |
AGTSFMMtPYVVTRY |
in vitro |
|
| pmid |
sentence |
| 10715136 |
Activation of JNK3 alpha 1 requires both MKK4 and MKK7. both MKK4 and MKK7 were required for bisphosphorylation and maximal enzyme activity. a processive mechanism for JNK3R1 activation that requires phosphorylation of Thr 221 by MKK7 prior to phosphorylation of Tyr 223 by MKK4 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP2K7 | up-regulates
phosphorylation
|
MAPK10 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137609 |
Thr221 |
AGTSFMMtPYVVTRY |
Homo sapiens |
|
| pmid |
sentence |
| 15911620 |
Two mapkks, sek1 and mkk7, synergistically activate jnk. Sek1 prefers the tyr-185 residue, and mkk7 prefers the thr-183 residue (17, 19). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63972 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9890973 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1)these results indicate that hgk, a novel activator of the jnk pathway, may function through tak1, and that the hgk --> tak1 --> mkk4, mkk7 --> jnk kinase cascade may mediate the TNF-alphalpha signaling pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83732 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that mkk4 shows a striking preference for the tyrosine residue (tyr-185), and mkk7 a striking preference for the threonine residue (thr-183) in three sapk1/jnk1 isoforms tested (jnk1 alpha 1, jnk2 alpha 2 and jnk3 alpha 1)these results indicate that hgk, a novel activator of the jnk pathway, may function through tak1, and that the hgk --> tak1 --> mkk4, mkk7 --> jnk kinase cascade may mediate the TNF-alphalpha signaling pathway. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAP3K2 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25190348 |
MEKK2 can phosphorylate and activate MAP2K proteins MKK7 and MEK5, thereby promoting activation of JNK and ERK5, respectively [ xref ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK2 | up-regulates
binding
|
MAP2K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10660600 |
Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K5 | up-regulates
phosphorylation
|
MAP2K7 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161766 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19920149 |
Ask1 is a member of a mapkkk family and functions as an upstream kinase engaged in c-jun nh2-terminal kinase (jnk)/p38 signaling via the phosphorylation and activation of mapkks, such as mkk3, -4, -6, and -7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11959862 |
Activation of mkk7 by ask1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TNF-alpha Signaling |
| + |
FLNA | up-regulates activity
binding
|
MAP2K7 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260628 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20156194 |
We used Filamin-A-deficient cells to show that Filamin A enhances MKK7 activation and is important for synergistic stress-induced JNK activation in vivo. Thus Filamin A is a novel member of the group of scaffold proteins whose function is to link two MAPKKs together and promote JNK activation. The present study provides evidence that Filamin A is one of the ‘binder’ molecules presumed to directly and closely connect MKK4 and MKK7 so that they can mediate this tyrosine/threonine phosphorylation. We showed that Filamin A (as well as Filamin B and C) associate with MKK7 and MKK4, but not with JNK1 itself |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
MAP3K5 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274148 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110930 |
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TNF-alpha Signaling |
| + |
MAPK8IP2 | up-regulates
binding
|
MAP2K7 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490659 |
Both jip1 and jip2 selectively bind the mapkk isoform mkk7. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59944 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733513 |
Thus, both jip1 and jip2 selectively bind the mapkk isoform mkk7. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274146 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110930 |
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21552290 |
TAK1 also phosphorylates and activates MKK6 and MKK7, leading to the activation of p38 and JNK kinase pathways, which may also contribute to disease pathogenesis ( |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Toll like receptors |
| + |
MAP3K20 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11416147 |
We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243342 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12220515 |
This result suggests that ZAK activates JNK/SAPK mediated by downstream target, MKK7 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SH3RF1 | up-regulates
binding
|
MAP2K7 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12514131 |
We confirmed that posh binds activated rac1 and find that it also binds all mlk family members tested and interacts with mkk4/7 as well as jnk1 and jnk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIPK2 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280105 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35115556 |
Collectively, the results suggest that RIPK2 binds to and activates MKK7.|Radioactive in vitro kinase assay showed that RIPK2 can directly phosphorylate kinase-dead (K149A) MKK7 (Fig.\u00a0 xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K12 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279630 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28111074 |
Collectively, these data suggest the hypothesis that ApoE activates DLK by increasing its levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K7 | up-regulates activity
phosphorylation
|
JNK |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83725 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062067 |
Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP2K7 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73906 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10629060 |
These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274147 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110930 |
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors |
| + |
MAPK8IP1 | up-regulates
binding
|
MAP2K7 |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70848 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490659 |
Both jip1 and jip2 selectively bind the mapkk isoform mkk7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDR62 | up-regulates activity
relocalization
|
MAP2K7 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271716 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 30566428 |
In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP3K13 | up-regulates
phosphorylation
|
MAP2K7 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11726277 |
Lzk directly phosphorylated and activated mkk7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MAP2K7
- 
- 