Relation Results

Summary

Name CDH17
Full Name Cadherin-17
Synonyms Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin |
Primary ID Q12864
Links - -
Type protein
Relations 4
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadhe ...
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Type: Score: Layout: SPV 
0.3170.6990.80.413HNF1ACDH17CTNNB1calcium(2+)CDX2

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Relations
Regulator
Mechanism
target
score ℹ
+ HNF1Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation CDH17 0.317
Identifier Residue Sequence Organism Cell Line
SIGNOR-253970 Homo sapiens HEP-3B Cell, MHCC-97 Cell
pmid sentence
The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which modulate the CDH17 promoter activities in two HCC cell lines (Hep3B and MHCC97L)
Publications: 1 Organism: Homo Sapiens
+ CDH17up-regulates activity img/direct-activation.png binding CTNNB1 0.699
Identifier Residue Sequence Organism Cell Line
SIGNOR-265856 Homo sapiens
pmid sentence
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin
Publications: 1 Organism: Homo Sapiens
+ calcium(2+)up-regulates activity img/direct-activation.png chemical activation CDH17 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-265834 Homo sapiens
pmid sentence
Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis.
Publications: 1 Organism: Homo Sapiens
+ CDX2up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDH17 0.413
Identifier Residue Sequence Organism Cell Line
SIGNOR-253963 Homo sapiens HEP-3B Cell, MHCC-97 Cell
pmid sentence
The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which modulate the CDH17 promoter activities in two HCC cell lines (Hep3B and MHCC97L)
Publications: 1 Organism: Homo Sapiens
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