4.0
Summary
| Name |  TRIM26View Modifications |
| Full Name | Tripartite motif-containing protein 26 |
| Synonyms | Acid finger protein, AFP, RING finger protein 95, Zinc finger protein 173 | RNF95, ZNF173 |
| Primary ID | Q12899 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRIM26 | down-regulates quantity by destabilization 
ubiquitination, polyubiquitination
|
IRF3 | 0.686 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
TRIM26 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM26 | down-regulates quantity
ubiquitination
|
NEIL1 | 0.246 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM26 | down-regulates quantity by destabilization
ubiquitination
|
NTHL1 | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |