Relation Results

Summary

Name NTHL1
Full Name Endonuclease III-like protein 1
Synonyms hNTH1, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycosylase/AP lyase | NTH1, OCTS3
Primary ID P78549
Links - -
Type protein
Relations 2
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), ...
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Type: Score: Layout: SPV 
0.2640.7TRIM26NTHL1Base-excision_repair

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Relations
Regulator
Mechanism
target
score ℹ
+ TRIM26down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NTHL1 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-278733 Homo sapiens
pmid sentence
We also demonstrated that TRIM26 directly polyubiquitylates NTH1 in cells and that TRIM26 targets newly synthesized NTH1 protein for ubiquitylation dependent degradation.
Publications: 1 Organism: Homo Sapiens
+ NTHL1up-regulates img/indirect-activation.png Base-excision_repair 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-275717
pmid sentence
The BER pathway is initiated by one of at least 11 distinct DNA glycosylases, depending on the type of lesion (Table 1).
Publications: 1
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