Summary

Name USP4
Full Name Ubiquitin carboxyl-terminal hydrolase 4
Synonyms EC 3.4.19.12, Deubiquitinating enzyme 4, Ubiquitin thioesterase 4, Ubiquitin-specific-processing protease 4, Ubiquitous nuclear protein homolog | UNP, UNPH
Primary ID Q13107
Links - -
Type protein
Relations 4
Function Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). Deubiquitinates HAS2 (PubMed:28604766). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:22347420, ECO:0000269|PubMed:25404403, ECO:0000269|PubMed:28604766}.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AKT1up-regulates quantity by stabilization img/direct-activation.png phosphorylation USP4 0.478
Publications: 1 Organism: Homo Sapiens
+ USP4down-regulates activity img/direct_inhibition.png deubiquitination PRPF3 0.501
Publications: 1 Organism: Homo Sapiens
+ USP4up-regulates quantity by stabilization img/direct-activation.png deubiquitination BRAP 0.271
Publications: 1 Organism: Homo Sapiens
+ DNPEPdown-regulates quantity by destabilization img/direct_inhibition.png cleavage USP4 0.2
Publications: 1