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Summary
Name
SRSF5
View Modifications
Full Name
Serine/arginine-rich splicing factor 5
Synonyms
Delayed-early protein HRS, Pre-mRNA-splicing factor SRP40, Splicing factor, arginine/serine-rich 5 | HRS, SFRS5, SRP40
Primary ID
Q13243
Links
-
-
Type
protein
Relations
2
Function
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
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Refine search:
by mechanism
none
phosphorylation
ubiquitination
by effect
none
up-regulates activity
down-regulates quantity by destabilization
by organism:
none
Rattus norvegicus
Homo sapiens
by tissue:
none
by cell-line
none
▶
Modifications Tables
SRSF5 as Target
Residue
Sequence
Modifier
Effect
Modification
Ser86
GRGRGRYsDRFSSRR
AKT2
activation
phosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
AKT2
up-regulates activity
phosphorylation
SRSF5
0.368
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-262633
Ser86
GRGRGRYsDRFSSRR
Rattus norvegicus
pmid
sentence
15684423
Here we show that Akt2 kinase phosphorylated SRp40 in vivo and in vitro. Mutation of Ser86 on SRp40 blocked in vitro phosphorylation.
Publications:
1
Organism:
Rattus Norvegicus
+
SMURF1
down-regulates quantity by destabilization
ubiquitination
SRSF5
0.264
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-278665
Homo sapiens
pmid
sentence
29942010
K125 was also the major site of SRSF5 ubiquitylation mediated by Smurf1.|Smurf1 targets SRSF5 for degradation upon low glucose
Publications:
1
Organism:
Homo Sapiens