Relation Results

Summary

Name PTK7
Full Name Inactive tyrosine-protein kinase 7
Synonyms Colon carcinoma kinase 4, CCK-4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7 | CCK4
Primary ID Q13308
Links - -
Type protein
Relations 2
Function Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) ...
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Type: Score: Layout: SPV 
0.20.412RACK1PTK7CTNNB1

Relations

Regulator
Mechanism
target
score
+ up-regulates img/direct-activation.png binding PTK7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-172322 Homo sapiens
pmid sentence
Here, we identify rack1 as a novel interaction partner of ptk7. Mechanistically, rack1 is necessary for the ptk7-mediated membrane localization of dishevelled (dsh). Rack1 facilitates the ptk7-dsh interaction by recruiting pkcdelta1, a known effector of dsh membrane translocation.
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.412
Identifier Residue Sequence Organism Cell Line
SIGNOR-199536 Homo sapiens
pmid sentence
Ptk7 has been strongly implicated in pcp and, like many pcp activators, is a negative regulator of beta-catenin-dependent wnt.
Publications: 1 Organism: Homo Sapiens
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