| + |
RACK1 | up-regulates
binding
|
PTK7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21350015 |
Here, we identify rack1 as a novel interaction partner of ptk7. Mechanistically, rack1 is necessary for the ptk7-mediated membrane localization of dishevelled (dsh). Rack1 facilitates the ptk7-dsh interaction by recruiting pkcdelta1, a known effector of dsh membrane translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTK7 | down-regulates
binding
|
CTNNB1 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Ptk7 has been strongly implicated in pcp and, like many pcp activators, is a negative regulator of beta-catenin-dependent wnt. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
PTK7 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24703874 |
Because Ptk7 lacks intrinsic kinase activitiy, we suggest a positive feedback model in which pre-existing active Src phosphorylates PTK7 enabling it to interact with the SH2 domain of additional Src molecules to result in further activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |