Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276318 |
Ser520 |
CRADELAsQDGR |
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
21460856 |
In the present study, we demonstrate that ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56γ3, B56γ2 and B56δ, after DNA damage. We further show that phosphorylation of B56γ3 at Ser510 leads to an increase in B56γ3-PP2A complexes, and direction of PP2A phosphatase activity toward the substrate p53, activating its tumor-suppressive functions. we show that Ser510 phosphorylation significantly enhances the ability of B56γ3 to inhibit cell proliferation and anchorage-independent growth. |
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