4.0
Summary
| Name |  MAPK8IP2
|
| Full Name | C-Jun-amino-terminal kinase-interacting protein 2 |
| Synonyms | JIP-2, JNK-interacting protein 2, Islet-brain-2, IB-2, JNK MAP kinase scaffold protein 2, Mitogen-activated protein kinase 8-interacting protein 2 | IB2, JIP2, PRKM8IPL |
| Primary ID | Q13387 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK8IP2 | up-regulates 
binding
|
MAPK9 | 0.572 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK8IP2 | up-regulates
binding
|
MAPK8 | 0.639 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK8IP2 | up-regulates
binding
|
MAP2K7 | 0.679 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MAPK8IP2 | up-regulates
binding
|
MAPK8IP1 | 0.654 |
| Publications: | 1 | Organism: | Homo Sapiens | |