+ |
OS9 | up-regulates quantity by stabilization
binding
|
TRPV4 |
0.382 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261064 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17932042 |
Here we report that OS-9, a ubiquitously expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4.Thus, OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation. Our data suggest that OS-9 functions as an auxiliary protein for TRPV4 maturation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ERN1 | up-regulates quantity by expression
transcriptional regulation
|
OS9 |
0.436 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261063 |
|
|
Homo sapiens |
|
pmid |
sentence |
18417469 |
Here we characterize the function in ER quality control of two proteins derived from alternative splicing of the OS-9 gene. OS-9.1 and OS-9.2 are ubiquitously expressed in human tissues and are amplified in tumors. They are transcriptionally induced upon activation of the Ire1/Xbp1 ER-stress pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |