3.0
Summary
| Name |  ERN1View Modifications |
| Full Name | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| Synonyms | Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a | IRE1 |
| Primary ID | O75460 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Pathways | COVID-19 Causal Network, SARS-CoV ER STRESS |
| Function | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ERN1 | up-regulates activity 
phosphorylation
|
ERN1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | E | down-regulates activity 
|
ERN1 | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | PPM1L | up-regulates activity
dephosphorylation
|
ERN1 | 0.315 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HSPA5 | down-regulates activity 
binding
|
ERN1 | 0.815 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | PDIA6 | down-regulates activity
|
ERN1 | 0.322 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | P4HB | down-regulates activity
binding
|
ERN1 | 0.44 |
| Publications: | 1 | |||
| + | ERN1 | up-regulates quantity by expression
post transcriptional regulation
|
XBP1 (isoform 2) | 0.638 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | ERN1 | up-regulates activity
binding
|
TRAF2 | 0.667 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | ERN1 | up-regulates quantity by expression 
transcriptional regulation
|
OS9 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERN1 | up-regulates
|
JUN | 0.394 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DAB2IP | up-regulates activity
binding
|
ERN1 | 0.376 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERN1 | down-regulates activity
|
JNK | 0.323 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | ER stress | up-regulates
|
ERN1 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network | |||
| + | Unfolded_Proteins | up-regulates
|
ERN1 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | SOD1 | up-regulates activity
binding
|
ERN1 | 0.322 |
| Publications: | 1 | Organism: | Mus Musculus | |