Summary

Name ADAM15
Full Name Disintegrin and metalloproteinase domain-containing protein 15
Synonyms ADAM 15, Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, MDC-15, Metargidin | MDC15
Primary ID Q13444
Links - -
Type protein
Relations 5
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ADAM15 0.38
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADAM15 0.22
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ADAM15 0.38
Publications: 1 Organism: Homo Sapiens