| + |
MARK3 | down-regulates activity 
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273868 |
Ser502 |
RMKGISRsLESVLSL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARK1 | down-regulates activity
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273866 |
Ser502 |
RMKGISRsLESVLSL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARK2 | down-regulates activity
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273867 |
Ser502 |
RMKGISRsLESVLSL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARK4 | down-regulates activity
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273865 |
Ser502 |
RMKGISRsLESVLSL |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNK1 | up-regulates activity 
phosphorylation
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274126 |
Tyr277 |
LGGARGRyVMGGPRP |
in vitro |
|
| pmid |
sentence |
| 36334623 |
We found a similar reduction in the levels of phosphorylation of Tyr277, which corresponds to the predicted major site of autophosphorylation within the activation loop of Tnk1 (Fig. 3C). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
14-3-3 | down-regulates activity
binding
|
TNK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273869 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 34504101 |
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNK1 | up-regulates quantity
binding
|
PLCG1 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10873601 |
GST-protein precipitations from cell lysates confirmed that GST-PLC-gamma1(SH3) associated with endogenously expressed Tnk1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TNK1
- 
- 