Relation Results

Summary

Name ARHGEF7
Full Name Rho guanine nucleotide exchange factor 7
Synonyms Beta-Pix, COOL-1, PAK-interacting exchange factor beta, p85 | COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Primary ID Q14155
Links - -
Type protein
Relations 7
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. ...
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Type: Score: Layout: SPV 
0.20.4680.4680.20.622PRKCGARHGEF7LRRK2CBLCRAC1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCGup-regulates img/direct-activation.png phosphorylation ARHGEF7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-205234 Ser518 LSASPRMsGFIYQGK Homo sapiens
pmid sentence
Pkc_ directly phosphorylates _pix at ser583 and indirectly at ser340 in cells. herefore, we propose that pkc_ positively modulates dopamine release through _2pix phosphorylation. The pkc_-_pix-cdc42/rac1 phosphorylation axis may provide a new therapeutic target for the treatment of parkinsonian syndrome
Identifier Residue Sequence Organism Cell Line
SIGNOR-205238 Ser761 DSLGRRSsLSRLEPS Homo sapiens
pmid sentence
Pkc_ directly phosphorylates _pix at ser583 and indirectly at ser340 in cells. herefore, we propose that pkc_ positively modulates dopamine release through _2pix phosphorylation. The pkc_-_pix-cdc42/rac1 phosphorylation axis may provide a new therapeutic target for the treatment of parkinsonian syndrome
Publications: 2 Organism: Homo Sapiens
+ LRRK2up-regulates img/direct-activation.png phosphorylation ARHGEF7 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-169221 Thr127 KVLSSLVtLNKVTAD Homo sapiens
pmid sentence
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Lrrk2 phosphorylates arhgef7 in vitro.Two Threonine residues, t107 and t143, within the arhgef7 n-terminus were identified with high confidence
Identifier Residue Sequence Organism Cell Line
SIGNOR-169225 Thr164 LGSQSLHtRTSKLFQ Homo sapiens
pmid sentence
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Lrrk2 phosphorylates arhgef7 in vitro.Two Threonine residues, t107 and t143, within the arhgef7 n-terminus were identified with high confidence
Publications: 2 Organism: Homo Sapiens
+ ARHGEF7up-regulates img/direct-activation.png binding LRRK2 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-169217 Homo sapiens
pmid sentence
Arhgef7 is interacting with lrrk2 in vitro and in vivo. Gtpase activity of full-length lrrk2 increases in the presence of recombinant arhgef7. Arhgef7 might act as a guanine nucleotide exchange factor for lrrk2
Publications: 1 Organism: Homo Sapiens
+ ARHGEF7down-regulates img/direct_inhibition.png binding CBLC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-118135 Homo sapiens
pmid sentence
Here, we show that activation of cdc42 protects the egf receptor from the negative regulatory activity of the c-cbl ubiquitin ligase. Activated cdc42 binds to p85cool-1 (for cloned-out-of-library)/beta-pix (for pak-interactive exchange factor), a protein that directly associates with c-cbl. This inhibits the binding of cbl by the egf receptor and thus prevents cbl from catalyzing receptor ubiquitination
Publications: 1 Organism: Homo Sapiens
+ ARHGEF7up-regulates img/indirect-activation.png RAC1 0.622
Identifier Residue Sequence Organism Cell Line
SIGNOR-155744 Homo sapiens
pmid sentence
We propose that the association of plcgamma1 with complexes containing git1 and beta-pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, plcgamma1 is also involved in the activation of cdc42 and rac1.
Publications: 1 Organism: Homo Sapiens
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