Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-240808 |
|
|
in vitro |
|
pmid |
sentence |
9020169 |
We demonstrate that both SIM1 and SIM2 can heterodimerize via their helix-loop-helix·PAS regions with ARNT, but not with AHR, and that they do not form homodimers. Furthermore, SIM1 may have a dual role, both negatively affecting AHR·ARNT binding to the XRE and also acting in concert with ARNT as a novel DNA-binding heterodimer. |
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