Summary

Name FHL2
Full Name Four and a half LIM domains protein 2
Synonyms FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3 | DRAL, SLIM3
Primary ID Q14192
Links - -
Type protein
Relations 3
Function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).

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Relations

Regulator Mechanism target score ℹ
+ RHOAup-regulates img/direct-activation.png relocalization FHL2 0.355
Publications: 1 Organism: Homo Sapiens
+ FHL2down-regulates activity img/direct_inhibition.png binding SPHK1 0.433
Publications: 1 Organism: Mus Musculus
Tissue: Heart
+ FHL2up-regulates img/direct-activation.png binding AR 0.538
Publications: 1 Organism: Homo Sapiens
Tissue: Prostate Gland