3.0
Summary
| Name |  SPHK1View Modifications |
| Full Name | Sphingosine kinase 1 |
| Synonyms | SK 1, SPK 1 | SPHK, SPK |
| Primary ID | Q9NYA1 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ERK1/2 | up-regulates 
phosphorylation
|
SPHK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
SPHK1 | 0.55 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EIF2AK2 | up-regulates activity
phosphorylation
|
SPHK1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | up-regulates
phosphorylation
|
SPHK1 | 0.593 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KC1 | up-regulates activity
binding
|
SPHK1 | 0.391 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | Gbeta | up-regulates
phosphorylation
|
SPHK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FHL2 | down-regulates activity 
binding
|
SPHK1 | 0.431 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Heart | |||
| + | KLF14 | up-regulates quantity by expression
transcriptional regulation
|
SPHK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |