+ |
GSK3B | up-regulates
phosphorylation
|
CRMP1 |
0.447 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-145991 |
Ser518 |
KYATPAPsAKSSPSK |
Homo sapiens |
Neuron |
pmid |
sentence |
16611631 |
Using in vitro kinase assays and pharmacological inhibition of gsk3 as described above for crmp2 and crmp4, it was found that thr509 (and presumably ser518 and thr514) of human crmp1 is phosphorylated by gsk3, following priming of ser522 by cdk5 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-145995 |
Thr509 |
PVYEVPAtPKYATPA |
Homo sapiens |
Neuron |
pmid |
sentence |
16611631 |
In summary, phosphorylation of thr509 of human crmp1 appears to be regulated by two mechanisms; direct phosphorylation by cdk5, or by priming of ser522 by cdk5 followed by sequential phosphorylation of ser518, thr514, and thr509 by gsk3. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-145999 |
Thr514 |
PATPKYAtPAPSAKS |
Homo sapiens |
Neuron |
pmid |
sentence |
16611631 |
Using in vitro kinase assays and pharmacological inhibition of gsk3 as described above for crmp2 and crmp4, it was found that thr509 (and presumably ser518 and thr514) of human crmp1 is phosphorylated by gsk3, following priming of ser522 by cdk5 |
|
Publications: |
3 |
Organism: |
Homo Sapiens |
+ |
CDK5 | up-regulates
phosphorylation
|
CRMP1 |
0.608 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-159314 |
Ser522 |
PAPSAKSsPSKHQPP |
Homo sapiens |
Neuron |
pmid |
sentence |
18003833 |
These findings suggest that sema3a-induced spine development is regulated by phosphorylation of crmp1 by cdk5. Introduction of crmp1-wt, but not crmp1-t509a/s522a, a crmp1 mutant that cannot be phosphorylated by cdk5, rescued the defect in sema3a responsiveness. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-159318 |
Thr509 |
PVYEVPAtPKYATPA |
Homo sapiens |
Neuron |
pmid |
sentence |
18003833 |
These findings suggest that sema3a-induced spine development is regulated by phosphorylation of crmp1 by cdk5. Introduction of crmp1-wt, but not crmp1-t509a/s522a, a crmp1 mutant that cannot be phosphorylated by cdk5, rescued the defect in sema3a responsiveness. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-145912 |
Thr509 |
PVYEVPAtPKYATPA |
Homo sapiens |
Neuron |
pmid |
sentence |
16611631 |
In summary, phosphorylation of thr509 of human crmp1 appears to be regulated by two mechanisms; direct phosphorylation by cdk5, or by priming of ser522 by cdk5 followed by sequential phosphorylation of ser518, thr514, and thr509 by gsk3. |
|
Publications: |
3 |
Organism: |
Homo Sapiens |