+ |
ABL1 | up-regulates activity
phosphorylation
|
RBM39 |
0.329 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262609 |
Tyr95 |
DRRFRGRyRSPYSGP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
27018250 |
In this paper, we report that RBM39 interacts with the nonreceptor tyrosine kinase c-Abl. Both the Src homology (SH) 2 and SH3 domains of c-Abl interact with RBM39. The major tyrosine phosphorylation sites on RBM39 that are phosphorylated by c-Abl are Y95 and Y99, as demonstrated by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) and mutational analysis. c-Abl was shown boost the transcriptional coactivation activity of RBM39 for ERα and PRβ in a tyrosine kinase-dependent manner. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262610 |
Tyr99 |
RGRYRSPySGPKFNS |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
27018250 |
In this paper, we report that RBM39 interacts with the nonreceptor tyrosine kinase c-Abl. Both the Src homology (SH) 2 and SH3 domains of c-Abl interact with RBM39. The major tyrosine phosphorylation sites on RBM39 that are phosphorylated by c-Abl are Y95 and Y99, as demonstrated by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) and mutational analysis. c-Abl was shown boost the transcriptional coactivation activity of RBM39 for ERα and PRβ in a tyrosine kinase-dependent manner. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
DCAF15 | down-regulates quantity by destabilization
polyubiquitination
|
RBM39 |
0.387 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272203 |
|
|
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
31819272 |
Indisulam promotes an interaction between RBM39 and the DCAF15 E3 ligase substrate receptor, leading to RBM39 ubiquitination and proteasome-mediated degradation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |