3.0
Summary
| Name |  NEDD9View Modifications |
| Full Name | Enhancer of filamentation 1 |
| Synonyms | hEF1, CRK-associated substrate-related protein, CAS-L, CasL, Cas scaffolding protein family member 2, Neural precursor cell expressed developmentally down-regulated protein 9, NEDD-9, Renal carcinoma antigen NY-REN-12, p105 | CASL, CASS2 |
| Primary ID | Q14511 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AURKA | up-regulates activity 
phosphorylation
|
NEDD9 | 0.588 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPN11 | down-regulates activity 
dephosphorylation
|
NEDD9 | 0.502 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEDD9 | up-regulates activity
binding
|
AURKA | 0.588 |
| Publications: | 1 | Organism: | Homo Sapiens | |