Summary

Name AXL
Full Name Tyrosine-protein kinase receptor UFO
Synonyms AXL oncogene | UFO
Primary ID P30530
Links - -
Type protein
Relations 14
Pathways iCAF signaling in PDAC, Chemokines PDAC
Inhibitors N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; cabozantinib; N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AXLup-regulates quantity by stabilization img/direct-activation.png phosphorylation MLKL 0.2
Publications: 1 Organism: Homo Sapiens
+ AXLup-regulates activity img/direct-activation.png phosphorylation YES1 0.2
Publications: 1 Organism: Homo Sapiens
+ AXLup-regulates activity img/direct-activation.png phosphorylation AXL 0.2
Publications: 3 Organism: In Vitro
+ GAS6up-regulates img/direct-activation.png binding AXL 0.906
Publications: 2 Organism: Homo Sapiens
+ N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamidedown-regulates activity img/direct_inhibition.png chemical inhibition AXL 0.8
Publications: 1 Organism: In Vitro
+ PROS1up-regulates img/direct-activation.png binding AXL 0.479
Publications: 1 Organism: Homo Sapiens
+ cabozantinibdown-regulates activity img/direct_inhibition.png chemical inhibition AXL 0.8
Publications: 1 Organism: Homo Sapiens
+ N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamidedown-regulates img/direct_inhibition.png chemical inhibition AXL 0.8
Publications: 1 Organism: Homo Sapiens
+ GAS6up-regulates activity img/direct-activation.png binding AXL 0.906
Publications: 1 Organism: Homo Sapiens
+ AXLup-regulates activity img/direct-activation.png binding Epithelial-mesenchymal_transition 0.7
Publications: 1 Organism: Homo Sapiens
+ AXLup-regulates img/indirect-activation.png Metastasis 0.7
Publications: 1 Organism: Homo Sapiens