Summary

Name SMC1A
Full Name Structural maintenance of chromosomes protein 1A
Synonyms SMC protein 1A, SMC-1-alpha, SMC-1A, Sb1.8 | DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1
Primary ID Q14683
Links - -
Type protein
Relations 3
Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SMC1A 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMC1A 0.2
Publications: 1 Organism: Homo Sapiens