| + |
Cohesin complex | up-regulates 
|
Chromosome_segregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30544080 |
Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMC3 | form complex 
binding
|
Cohesin complex |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263312 |
|
|
|
|
| pmid |
sentence |
| 28430577 |
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin |
|
| Publications: |
1 |
| + |
SGO1 | up-regulates quantity by stabilization 
binding
|
Cohesin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265264 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24055156 |
The complex between shugoshin and protein phosphatase 2A (Sgo1-PP2A) localizes to centromeres in mitosis, binds to cohesin in a reaction requiring Cdk-dependent phosphorylation of Sgo1, dephosphorylates cohesin-bound sororin, and protects a centromeric pool of cohesin from mitotic kinases and the cohesin inhibitor Wapl. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAG1 | form complex
binding
|
Cohesin complex |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267729 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 26220997 |
Integrator is a metazoan-specific multisubunit, multifunctional protein complex composed of 14 subunits named Int1–Int14 (Integrator subunits)  |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
TERB2 | up-regulates activity
relocalization
|
Cohesin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263306 |
|
|
|
|
| pmid |
sentence |
| 27025256 |
Terb1 and Sun1 are two key proteins linking the meiotic telomeres to the NE. Terb1 participates in telomere fortification by recruiting cohesins to the site |
|
| Publications: |
1 |
| + |
STAG | form complex
binding
|
Cohesin complex |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263314 |
|
|
|
|
| pmid |
sentence |
| 28430577 |
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin |
|
| Publications: |
1 |
| + |
TTM complex | up-regulates activity
relocalization
|
Cohesin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263307 |
|
|
|
|
| pmid |
sentence |
| 27025256 |
Terb1 and Sun1 are two key proteins linking the meiotic telomeres to the NE. Terb1 participates in telomere fortification by recruiting cohesins to the site |
|
| Publications: |
1 |
| + |
RAD21 | form complex
binding
|
Cohesin complex |
0.966 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263311 |
|
|
|
|
| pmid |
sentence |
| 28430577 |
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin |
|
| Publications: |
1 |
| + |
SMC1A | form complex
binding
|
Cohesin complex |
0.878 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263313 |
|
|
|
|
| pmid |
sentence |
| 28430577 |
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin |
|
| Publications: |
1 |
| + |
WAPL | down-regulates activity 
|
Cohesin complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265265 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17113138 |
We show that human Wapl interacts with cohesin throughout the cell cycle via cohesin's Scc1 and SA1/SA2 subunits and that Wapl forms a subcomplex with Pds5A|These results indicate that Wapl is required for the release of cohesin from both interphase chromatin and mitotic chromosomes, perhaps by facilitating opening of the cohesin ring or by modulating direct interactions between cohesin and DNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NIPBL | up-regulates activity
binding
|
Cohesin complex |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28914604 |
Scc2 (Nipbl) stimulates cohesin’s ABC-like ATPase and is essential for loading cohesin onto chromosomes. However, it is possible that the stimulation of cohesin’s ATPase by Scc2 also has a post-loading function, for example driving loop extrusion. Using fluorescence recovery after photobleaching (FRAP) and single-molecule tracking in human cells, we show that Scc2 binds dynamically to chromatin, principally through an association with cohesin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Cohesin complex
CPX-5989