Summary

Name LTBP1
Full Name Latent-transforming growth factor beta-binding protein 1
Synonyms LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1
Primary ID Q14766
Links - -
Type protein
Relations 1
Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).

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Relations

Regulator Mechanism target score ℹ
+ LTBP1up-regulates activity img/direct-activation.png binding TGFB1 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling