TGFbeta Signaling

Pathway ID: SIGNOR-TGFb

Description: The transforming growth factor beta (TGF-Beta) signaling pathway is involved in many cellular processes among which, the regulation of cell growth and differentiation. So, defects in TGF-Beta signaling pathways have been linked to uncontrolled cellular proliferation and carcinogenesis. Briefly, a TGF-Beta superfamily ligand induces the heteromeric complex formation of two serine/threonine kinase receptors, type I and type II TGF-Beta receptors. The type II receptor phosphorylates the type I receptor that, once activated, in turn phosphorylates downstream R-Smad proteins (in particular Smad2 and 3), activating them to transduce the signal to the nucleus with the help of the common partner Smad4 and thus participating in the regulation of target genes expression. Other members of the SMAD family of transcriptional regulators also participate in the regulation of the TGF-Beta signaling pathway. Moreover, other signaling pathways like the MAP kinase-ERK cascade are activated by TGF-Beta signaling.

Curated by: Lisa Petrilli

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

27 Seed Entities

Organism:
Name Primary ID
TGFBR2 P37173
AP1 SIGNOR-C154
JNK SIGNOR-PF15
MAP2K3 P46734
TGFBR1 P36897
CBP/p300 SIGNOR-C6
TGFB1 P01137
MAP2K6 P52564
SMAD6 O43541
SMAD3 P84022
ZFYVE9 O95405
TGFB2 P61812
SMAD2 Q15796
SMAD4 Q13485
FKBP1A P62942
SMAD3/SMAD4 SIGNOR-C9
SKI P12755
SMAD7 O15105
MAP3K7 O43318
MAPK14 Q16539
TRAF6 Q9Y4K3
MAP2K4 P45985
SMURF SIGNOR-PF29
RUNX2 Q13950
ATF2 P15336
SMAD2/SMAD4 SIGNOR-C8
SKIL P12757