| + |
TGFB1 | up-regulates 
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252282 |
|
|
|
|
| pmid |
sentence |
| 17326328 |
More than a dozen different proteins have been identified as angiogenic activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, platelet-derived endothelial growth factor, granulocyte colony-stimulating factor, placental growth factor, interleukin-8, hepatocyte growth factor, and epidermal growth factor |
|
| Publications: |
1 |
| + |
FGF9 | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780951 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195594 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity 
binding
|
TGFBR2 |
0.847 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236080 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 1310899 |
A cdna encoding the tgf-beta type ii receptor protein has been isolated by an expression cloning strategy. The cloned cdna, when transfected into cos cells, leads to overexpression of an approximately 80 kd protein that specifically binds radioiodinated tgf-beta 1. Excess tgf-beta 1 competes for binding of radioiodinated tgf-beta 1 in a dose-dependent manner and is more effective than tgf-beta 2. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer |
| + |
TGFB1 | up-regulates activity
binding
|
PIK3R1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
While association of the TGF_RI receptor with p85 requires TGF-_ stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression 
transcriptional regulation
|
RNF111 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14657019 |
Expression of arkadia is down-regulated by tgf-beta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
SFTPB |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254170 |
|
|
Homo sapiens |
Lung Epithelial Cell |
| pmid |
sentence |
| 18003659 |
TGF-beta represses transcription of pulmonary surfactant protein-B gene in lung epithelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
binding
|
PI3K |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252729 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
While association of the TGF_RI receptor with p85 requires TGF-_ stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Thyroid Hormone Metabolism |
| + |
TGFB1 | down-regulates quantity by repression 
transcriptional regulation
|
TSHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
TGF-β inhibits thyroid-stimulated hormone (TSH)-induced NIS mRNA and protein levels in a dose-dependent manner. This effect takes place at the transcriptional level, as TGF-β inhibits TSH-induced transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
DNAH10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265552 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 31836722 |
The protein expression of DNAH10 was assessed by Western blot analysis after stimulation of primary keratinocytes (P4) with inflammatory cytokine TNFα or growth factor TGF-β1 and their combination (Fig. 5C). Treatment with TNFα, TGF-β1, and their combination down regulated the expression of DNAH10 in keratinocytes after a 24-h-stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
TFAP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255428 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 21228219 |
TGFβ effectively inhibits expression of SALL2 and its regulator AP4 when added to quiescent fibroblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ITGA2 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253354 |
|
|
Homo sapiens |
MG-63 Cell |
| pmid |
sentence |
| 1744142 |
TGF-beta 1 decreases the biosynthesis of alpha 3 subunit but increases the production of alpha 2 subunit. IL-1 beta potentiates the effects of TGF-beta 1. Furthermore, in the presence of TGF-beta 1 the increase in the expression of alpha 1 subunit by IL-1 beta is even larger. Thus, IL-1 beta and TGF-beta 1, which usually have antagonistic functions in connective tissue, can regulate integrin expression in a synergistic way. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
binding
|
TGFB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885528 |
The active form of TGF-beta is a dimer stabilized by hydrophobic interactions and usually further strengthened by an intersubunit disulfide bridge. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, EBV infection, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
PAX6 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251874 |
|
|
Homo sapiens |
Lens Epithelial Cell Line |
| pmid |
sentence |
| 17251190 |
The effect of TGFbeta on Pax6 expression was studied in the FHL124 lens epithelial cell line and was found to cause up to a 50% reduction in Pax6 mRNA levels within 24 h. Pax6-stimulated activity of the Pax6 promoter is repressed by TGFβ signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates
binding
|
TGFBR1 |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
TGF-b ligands bind to TGF-b type II receptor (TbRII), which transphosphorylates and activates TGF-b type I receptor (TbRI). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
OMD |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16970923 |
We found tgf-beta1 to down regulate osad |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
binding
|
TGFBR1 |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196022 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22326956 |
TGF-beta signaling mediates a wide range of biological activities in development and disease. TGF-beta ligands signal through heterodimeric type I and type II receptors (TGF-beta receptor type I [TbetaRI, also known as ALK5 and TGFBR1] and TbetaRII) that are members of the serine/threonine kinase family. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22326956 |
In Tgfbr2fl/fl control MEPM cells, radioactive TGF-β2 ligands (12.5 kDa) bind to TβRI (53 kDa), TβRII (70 kDa), and TβRIII (100–200 kDa, highly glycosylated molecule) and form the ligand-receptor complexes of TβRI::TGF-β2 (65.5 kDa), TβRII::TGF-β2 (82.5 kDa), and TβRIII::TGF-β2 (112.5–212.5 kDa) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22703233 |
TGFbeta signals are transmitted via a cell surface receptor complex consisting of the TGFbeta type I receptor (TbetaRI) and TGFbeta type II receptor (TbetaRII). To initiate signal transduction, TGFbeta binds to TbetaRII, which in turn recruits TbetaRI, leading to the formation of a tetrameric receptor complex. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer |
| + |
FBN1 | up-regulates quantity
binding
|
TGFB1 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251888 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17242066 |
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a major contributor to the pathology of Marfan syndrome (MFS) and related diseases. In the presence of cell layer extracellular matrix, a fibrillin-1 sequence encoded by exons 44-49 releases endogenous TGFbeta1, thereby stimulating TGFbeta receptor-mediated Smad2 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
COL1A2 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8182090 |
Tgf-beta stimulates transcription of the human alpha 2(i) collagen gene (col1a2) promoter by increasing the affinity of an sp1-containing protein complex for its cognate dna-binding site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251713 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23936544 |
MAPKs have cis-acting regulatory elements in the mouse-TGF promoter region, which respond to various transcription factors, including specificity protein-1 and activating protein 1. Thus, it is possible that apoptotic cell-induced TGF-beta mRNA expression is mediated through activation of these transcription factors via MAPK signaling. Xiao et al. reported that all of the MAPK members, including p38/ERK/JNK, are required for apoptotic Jurkat cells up-regulation of TGF-beta production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | TGF-beta Signaling |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
SALL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255427 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 21228219 |
TGFβ effectively inhibits expression of SALL2 and its regulator AP4 when added to quiescent fibroblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates activity
|
CyclinE/CDK2 |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217502 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10611320 |
Tgf-beta treatment resulted in the specific inactivation of cyclin cdk2 complexes caused by absence of the activating thr(160) phosphorylation on cdk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ENPP1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252200 |
|
|
Homo sapiens |
Chondrocyte |
| pmid |
sentence |
| 20930330 |
TGF-β1 was shown to stimulate ANK and PC-1 expression in articular chondrocytes, and subsequent ePPi level, as well as to increase ePi uptake by inducing PiT-1 expression in a chondrogenic cell line. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
|
SHC1 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242631 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 17673906 |
We report that upon TGF__ stimulation, the activated TGF__ type I receptor (T_RI) recruits and directly phosphorylates ShcA proteins on tyrosine and serine. This dual phosphorylation results from an intrinsic T_RI tyrosine kinase activity that complements its well_defined serine_threonine kinase function. TGF___induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well_characterised pathway linking receptor tyrosine kinases with Erk MAP kinases. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Thyroid cancer |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2B |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7592908 |
The steadystate level of p15ink4b mrna was induced 30-fold upon tgf-beta treatment, implicating p15ink4b as a primary effector of the tgf-beta-mediated cell cycle arrest |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, TGF-beta Signaling, TGFb in cancer |
| + |
TGFB1 | up-regulates
|
Activated PSC |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38540204 |
Resident fibroblasts, especially PSC, have the ability to transdifferentiate from a “quiescent” retinoid/lipid storing phenotype in the normal pancreas to an “activated” α-smooth muscle-actin-producing myofibroblastic phenotype through tumor-derived stimuli such as cytokines (interleukin(IL)-1, IL-6, and IL-8 and tumor necrosis factor (TNF)-α), growth factors (platelet-derived growth factor (PDGF) and tumor growth factor (TGF)-β), and reactive oxygen species [33]. Activated PSCs can, in turn, produce autocrine factors such as PDGF, TGF-β, and cytokines, which may contribute to a looping mechanism promoting a desmoplastic reaction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Pancreas |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ACTA2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988769 |
A TGF-β1 response element that has a sequence different to that known for Smad binding has been identified in the α- SM actin promoter and seems to be essential for expression of α-SM actin in both SM cells 72 and myofibroblasts73 . How TGF-β1 activates expression of α-SM actin through this TGF-β1 control element is, as yet, unknown |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroblast |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
SLC5A5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259912 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
The sodium/iodide symporter mediates the active transport of iodide in thyroid follicular cells. A number of agents regulate NIS expression; among these, TGF-β is a potent inhibitor of both iodide uptake and NIS gene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ACTA2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251923 |
|
|
Homo sapiens |
Lung Fibroblast |
| pmid |
sentence |
| 20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MMP2 | up-regulates
cleavage
|
TGFB1 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10652271 |
We also demonstrate that mmp-9, as well as its relative, mmp-2, cleave latent transforming growth factor-beta (tgf-beta), which constitutes a novel mechanism of tgf-beta activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAF | up-regulates quantity
relocalization
|
TGFB1 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251987 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19861538 |
The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. BRAF induces TGFβ secretion leading to NIS repression in a MEK-ERK–independent manner but cooperating with the MEK-ERK pathway to induce strong tumor invasion, two major traits acquired during PTC progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Thyroid cancer |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35816922 |
COL1A1 expression is regulated by upstream genes and the binding of regulatory elements at multiple binding sites upstream of its promoter. During cancer progression, CAFs reorganize and cross-link COL1A1, which accumulates and stiffens in the tumor stroma [12], [18]. This process may involve fibrogenic factors, especially transforming growth factor-beta (TGF-β1). Indeed, a TGF-β1 response sequence was identified 174 nucleotides upstream of the COL1A1 transcription start site, and was shown to up-regulate COL1A1 promoter activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Pancreas |
| + |
FGF2 | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780951 |
Fgf-2 and fgf-9 increased expression of other osteogenic factors bmp-2 and tgf-beta1, and endogenous fgf/ fgfr signaling is a positive upstream regulator of the bmp-2 gene in calvarial osteoblasts |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Activated PSC | up-regulates quantity
|
TGFB1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38540204 |
Resident fibroblasts, especially PSC, have the ability to transdifferentiate from a “quiescent” retinoid/lipid storing phenotype in the normal pancreas to an “activated” α-smooth muscle-actin-producing myofibroblastic phenotype through tumor-derived stimuli such as cytokines (interleukin(IL)-1, IL-6, and IL-8 and tumor necrosis factor (TNF)-α), growth factors (platelet-derived growth factor (PDGF) and tumor growth factor (TGF)-β), and reactive oxygen species [33]. Activated PSCs can, in turn, produce autocrine factors such as PDGF, TGF-β, and cytokines, which may contribute to a looping mechanism promoting a desmoplastic reaction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Pancreas |
| + |
TGFB1 | down-regulates
|
SKP2 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171013 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21212736 |
Skp2, a f-box protein that determines the substrate specificity for scf ubiquitin ligase, has recently been demonstrated to be degraded by cdh1/apc in response to tgfbeta signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates
|
MEF2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235602 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14739161 |
Tgf-beta was shown to inhibit myogenin and mef2d expression and myotube formation in c2c12. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TGFB1 | up-regulates
|
NfKb-p65/p50 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179179 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18586026 |
These data show that tgf-beta-induced nf-kappab activation is through tak1/mek-mediated aktactivation, which is essential for tgf-beta to support of osteoclast survival |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection |
| + |
TGFB1 | up-regulates quantity by expression
|
CDKN1B |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17283133 |
In normal primary endometrial epithelial cells (eecs), tgfbeta directly induced a dose-dependent increase in p27 protein levels and its nuclear localization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
MYOCD |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21673106 |
These results indicate that (i) tgf- and klf4 regulate myocd transcription positively and negatively, respectively. When __90% of smad4 was down-regulated myocd mrna induction by tgf- was abolished, suggesting that smad4 plays a critical role in transcriptional activation of the myocd gene |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
CCNA2 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7592630 |
Expression of one of these components, cyclin a, is inhibited by tgf-beta treatment. We have identified a 760-base pair fragment of the human cyclin a gene promoter that is sufficient to confer tgf-beta responsiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates activity
|
PIK3CG |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217812 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
First, TGF-beta can rapidly activate PI3K, as indicated by the phosphorylation of its downstream effector Akt |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITGB8 | up-regulates
|
TGFB1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117386 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11970960 |
Integrin _v_8-mediated tgf_ activation is also required to regulate neurovascular homeostasis in the adult brain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
GGCX | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261231 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 31539109 |
GGCX can regulate osteoporosis via promoting the TGFβ/smad signaling pathway, facilitating BMSCs osteogenic differentiation, and inhibiting BMSCs adipogenic differentiation. The transfection of pcDNA-GGCX plasmid significantly promoted BMSC cell proliferation, increased calcified nodule formation, inhibited adipogenic differentiation, enhanced ALP activity, elevated RUNX2, and OPN mRNA expressions, and upregulated TGFβ1, Smad2, and Smad7 expressions (p < 0.05). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251740 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 23936544 |
MAPKs have cis-acting regulatory elements in the mouse-TGF promoter region, which respond to various transcription factors, including specificity protein-1 and activating protein 1. Thus, it is possible that apoptotic cell-induced TGF-β mRNA expression is mediated through activation of these transcription factors via MAPK signaling. Xiao et al. reported that all of the MAPK members, including p38/ERK/JNK, are required for apoptotic Jurkat cells up-regulation of TGF-β production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TGFB1 | up-regulates activity
binding
|
PPP2R2A |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19114990 |
The Balpha subunit interacts directly with activated T_RI. The Balpha interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
transcriptional regulation
|
TGFB1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254517 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
HBB |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251797 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TDGF1 | down-regulates activity
binding
|
TGFB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17030617 |
Ere, we provide evidence supporting a novel mechanism in which Cripto inhibits the tumor suppressor function of TGF-beta. Cripto bound TGF-beta and reduced the association of TGF-beta with its type I receptor, TbetaRI. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
BGLAP |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107248 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
Tgf-beta inhibited the expression of the cbfa1 and_ osteocalcin_ genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates activity
binding
|
PAX8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14623893 |
DNA Binding Activity of Pax8 to the NIS Promoter Is Reduced by Smad3. TGF-β decreases Pax8 DNA binding to the NIS promoter and also found a physical interaction between Pax8 and Smad3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TGFB1 | up-regulates
binding
|
TGFBR2 |
0.847 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255030 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
TGF-b ligands bind to TGF-b type II receptor (TbRII), which transphosphorylates and activates TGF-b type I receptor (TbRI). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer |
| + |
MMP9 | up-regulates
cleavage
|
TGFB1 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10652271 |
We also demonstrate that mmp-9, as well as its relative, mmp-2, cleave latent transforming growth factor-_ (tgf-_), which constitutes a novel mechanism of tgf-_ activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
TAGLN |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
ITGA3 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253353 |
|
|
Homo sapiens |
MG-63 Cell |
| pmid |
sentence |
| 1744142 |
TGF-beta 1 decreases the biosynthesis of alpha 3 subunit but increases the production of alpha 2 subunit. IL-1 beta potentiates the effects of TGF-beta 1. Furthermore, in the presence of TGF-beta 1 the increase in the expression of alpha 1 subunit by IL-1 beta is even larger. Thus, IL-1 beta and TGF-beta 1, which usually have antagonistic functions in connective tissue, can regulate integrin expression in a synergistic way. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates
|
TGFB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23324179 |
Amp-activated protein kinase inhibits tgf-__-, angiotensin ii-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
SLC20A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252202 |
|
|
Homo sapiens |
Chondrocyte |
| pmid |
sentence |
| 20930330 |
TGF-β1 was shown to stimulate ANK and PC-1 expression in articular chondrocytes, and subsequent ePPi level, as well as to increase ePi uptake by inducing PiT-1 expression in a chondrogenic cell line. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
LPP |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191768 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22886954 |
Tgf-_1-induced lpp expression dependant on rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
KRT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16258965 |
TGFβ1 and TGFβ2 induce loss of epithelial morphology, cytokeratin, and membrane-associated Zonula Occludens-1 and increase the smooth muscle markers calponin and caldesmon |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
COL4A1 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251922 |
|
|
Homo sapiens |
Lung Fibroblast |
| pmid |
sentence |
| 20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
RUNX2 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
Tgf-b caused a 50% reduction of cbfa1 mrna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
TGFB1 | down-regulates
|
MYOG |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235728 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14739161 |
Tgf-beta was shown to inhibit myogenin and mef2d expression and myotube formation in c2c12. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ENG |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255202 |
|
|
Homo sapiens |
Hepatic Stellate Cell |
| pmid |
sentence |
| 21146604 |
In hepatic stellate cells, TGF-β1 upregulates endoglin expression most likely via the ALK5 pathway and requires the SP1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
LPL |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251847 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 11742878 |
TGF-β1 inhibited gene expression and cell surface activity of LPL. TGF-β1 did not have an effect on LPL activity when it was added directly to the LPL activity assay (data not shown); however, as shown in the Table, TGF-β1 significantly reduced LPL mRNA by 55.0% |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Phagocytosis | up-regulates quantity
|
TGFB1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255444 |
|
|
|
Macrophage |
| pmid |
sentence |
| 22933625 |
Furthermore, phagocytosis of apoptotic neutrophils by M1 macrophages increased production of the Th2 cytokine TGFβ by the macrophages, while reducing expression of the Th1 cytokines IL-1β and TNF-α, reflecting a shift toward an M2 phenotype |
|
| Publications: |
1 |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
ANKH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252201 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20930330 |
TGF-β1 was shown to stimulate ANK and PC-1 expression in articular chondrocytes, and subsequent ePPi level, as well as to increase ePi uptake by inducing PiT-1 expression in a chondrogenic cell line. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates
|
CDK2 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10611320 |
Tgf-beta treatment resulted in the specific inactivation of cyclin cdk2 complexes caused by absence of the activating thr(160) phosphorylation on cdk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
LTBP1 | up-regulates activity
binding
|
TGFB1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235754 |
|
|
Homo sapiens |
BAEC Cell |
| pmid |
sentence |
| 8432736 |
Together these data form strong support for the hypothesis that the LTBP plays an essential role in the activation of latent TGF-b in heterotypic cultures. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
TGFB1 | down-regulates quantity by repression
transcriptional regulation
|
CDK4 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8402878 |
Here we show that tgf beta 1 induces suppression of cdk4 synthesis in g1 in mink lung epithelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
3.0
TGFB1
- 
- 