+ |
PLK1 | down-regulates activity
phosphorylation
|
MAD2L1BP |
0.384 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265970 |
Ser102 |
KHFYRKPsPQAEEML |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
31118282 |
Purified Plk1 bound to p31comet and phosphorylated it, resulting in the suppression of its activity (with TRIP13) to disassemble checkpoint complexes. We conclude that Plk1 phosphorylates p31 on S102 and on five additional sites. The phosphorylation of the additional sites was possibly not detectable in HeLa cell extracts due to the opposing action of protein phosphatases. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAD2L1BP | down-regulates quantity by destabilization
binding
|
MCC |
0.474 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265979 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
25092294 |
We have indeed showed that TRIP13 action to disassemble the Cdc20–Mad2 complex requires the presence of p31comet (Fig. 3A). We furthermore found that the joint action of TRIP13 and p31comet is also required for the release of Mad2 from MCC, for the complete disassembly of MCC and for relieving APC/C from checkpoint inhibition (Figs. 3 and and4).4). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAD2L1BP | up-regulates activity
binding
|
TRIP13 |
0.483 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265971 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
25092294 |
We have indeed showed that TRIP13 action to disassemble the Cdc20–Mad2 complex requires the presence of p31comet (Fig. 3A). We furthermore found that the joint action of TRIP13 and p31comet is also required for the release of Mad2 from MCC, for the complete disassembly of MCC and for relieving APC/C from checkpoint inhibition (Figs. 3 and and4).4). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |