| + |
MCC | down-regulates activity 
binding
|
APC-c |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265977 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC20 | form complex 
binding
|
MCC |
0.978 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265976 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAD2L1 | form complex
binding
|
MCC |
0.963 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265973 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAD2L1BP | down-regulates quantity by destabilization
binding
|
MCC |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265979 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
We have indeed showed that TRIP13 action to disassemble the Cdc20–Mad2 complex requires the presence of p31comet (Fig. 3A). We furthermore found that the joint action of TRIP13 and p31comet is also required for the release of Mad2 from MCC, for the complete disassembly of MCC and for relieving APC/C from checkpoint inhibition (Figs. 3 and and4).4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIP13 | down-regulates quantity by destabilization
binding
|
MCC |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265972 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
We have indeed showed that TRIP13 action to disassemble the Cdc20–Mad2 complex requires the presence of p31comet (Fig. 3A). We furthermore found that the joint action of TRIP13 and p31comet is also required for the release of Mad2 from MCC, for the complete disassembly of MCC and for relieving APC/C from checkpoint inhibition (Figs. 3 and and4).4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1B | form complex
binding
|
MCC |
0.978 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265974 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB3 | form complex
binding
|
MCC |
0.965 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265975 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25092294 |
The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3 associated with the APC/C activator Cdc20. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MCC
CPX-3946