Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260917 |
Tyr705 |
DPGSAAPyLKTKFIC |
Homo sapiens |
|
pmid |
sentence |
12637586 |
In addition, RET/PTC-mediated cellular transformation and proliferation of transformed cells require tyrosine 705 phosphorylation of STAT3 in NIH3T3 cells. We conclude that STAT3 activation by the RET/PTC tyrosine kinase is one of the critical signaling pathways for the regulation of specific genes, such as cyclin D1, vascular endothelial growth factor, and intercellular adhesion molecule 1, and for cellular transformation. |
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