Relation Results

Summary

Name SAFB
Full Name Scaffold attachment factor B1
Synonyms SAF-B, SAF-B1, HSP27 estrogen response element-TATA box-binding protein, HSP27 ERE-TATA-binding protein | HAP, HET, SAFB1
Primary ID Q15424
Links - -
Type protein
Relations 2
Function Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (co ...
View More

Viewer

Type: Score: Layout: SPV 
0.20.365BRCA1SAFBFUS

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by stabilization img/direct-activation.png ubiquitination SAFB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278624 Homo sapiens
pmid sentence
These results suggest that the BRCA1 and BARD1 heterodimer ubiquitinates SAFB and increases SAFB protein levels.
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization FUS 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-262821 Homo sapiens HEK-293 Cell
pmid sentence
SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription| In addition, depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif.
Publications: 1 Organism: Homo Sapiens
a simple tooltip