| Name
|
 SAFB
|
| Full Name |
Scaffold attachment factor B1 |
| Synonyms |
SAF-B, SAF-B1, HSP27 estrogen response element-TATA box-binding protein, HSP27 ERE-TATA-binding protein | HAP, HET, SAFB1 |
| Primary ID |
Q15424 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). |
3.0
relocalization