| + |
CASP3 | up-regulates activity 
cleavage
|
STK4 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109874 |
Asp326 |
NSEEDEMdSGTMVRA |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109878 |
Asp349 |
RVASTMTdGANTMIE |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
STK4 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256444 |
Asp326 |
NSEEDEMdSGTMVRA |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256445 |
Asp349 |
RVASTMTdGANTMIE |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
STK4 |
phosphorylation
|
H2BC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171009 |
Ser15 |
APAPKKGsKKAITKA |
Homo sapiens |
|
| pmid |
sentence |
| 21212262 |
The mst1 is a serine/threonine kinase that is activated upon apoptotic stimulation, which in turn activates its downstream targets, jnk/p38, histone h2b and foxo. Mst1 induces apoptosis by phosphorylating histone h2b on a relatively conserved site, ser-14 in mammalian cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
FOXO |
0.673 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253001 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253000 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252999 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252998 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1 |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
STK4 | up-regulates
phosphorylation
|
FOXO3 |
0.673 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191851 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178190 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
FOXO1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178186 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191847 |
Ser212 |
SSAGWKNsIRHNLSL |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
STK4 | up-regulates activity
phosphorylation
|
STK4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247569 |
Ser327 |
SEEDEMDsGTMVRAV |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12223493 |
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylationwas also highly autophosphorylated at the newly identified Thr(177) and Thr(387) residues |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247573 |
Thr177 |
VAGQLTDtMAKRNTV |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12223493 |
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylationwas also highly autophosphorylated at the newly identified Thr(177) and Thr(387) residues |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247577 |
Thr183 |
DTMAKRNtVIGTPFW |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12223493 |
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylationWe define Thr(183) in subdomain VIII as a primary site of phosphoactivation. Thr(187) is also critical for kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247581 |
Thr187 |
KRNTVIGtPFWMAPE |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12223493 |
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylationWe define Thr(183) in subdomain VIII as a primary site of phosphoactivation. Thr(187) is also critical for kinase activity. |
|
| Publications: |
4 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Hippo Signaling |
| + |
MAPK8 | up-regulates
phosphorylation
|
STK4 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162327 |
Ser82 |
SIMQQCDsPHVVKYY |
Homo sapiens |
|
| pmid |
sentence |
| 20028971 |
C-jun n-terminal kinase enhances mst1-mediated pro-apoptotic signaling through phosphorylation at serine 82. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
LATS2 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175821 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201298 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175825 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201302 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
LATS1 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133551 |
Ser909 |
HQRCLAHsLVGTPNY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
We show that Mst2 and hWW45 interact with each other in human cells and that both Mst2 and Mst1 are able to phosphorylate Lats1 and Lats2, thereby stimulating Lats kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133555 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 15688006 |
We show that Mst2 and hWW45 interact with each other in human cells and that both Mst2 and Mst1 are able to phosphorylate Lats1 and Lats2, thereby stimulating Lats kinase activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
MOB1A |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175829 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201306 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175833 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201310 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
MOB1B |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175837 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201314 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175841 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201318 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
AKT1 | down-regulates 
phosphorylation
|
STK4 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252507 |
Thr120 |
IIRLRNKtLTEDEIA |
Homo sapiens |
|
| pmid |
sentence |
| 19940129 |
Akt interacts with mst1 and phosphorylates a highly conserved residue threonine 120 of mst1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of thr(183). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252537 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Full activation of mst1 requires an activation cleavage that is prevented by the phosphorylation of thr-387 by akt. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates
phosphorylation
|
STK4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161829 |
Thr120 |
IIRLRNKtLTEDEIA |
Homo sapiens |
|
| pmid |
sentence |
| 19940129 |
Akt interacts with mst1 and phosphorylates a highly conserved residue threonine 120 of mst1, which leads to inhibition of its kinase activity and nuclear translocation as well as the autophosphorylation of thr(183). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201121 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Full activation of mst1 requires an activation cleavage that is prevented by the phosphorylation of thr-387 by akt. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK4 |
phosphorylation
|
TNNI3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182049 |
Thr129 |
ITEIADLtQKIFDLR |
Homo sapiens |
|
| pmid |
sentence |
| 18986304 |
Ms analysis indicated that mst1 phosphorylates ctni at thr(31), thr(51), thr(129) and thr(143). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182053 |
Thr143 |
RGKFKRPtLRRVRIS |
Homo sapiens |
|
| pmid |
sentence |
| 18986304 |
Ms analysis indicated that mst1 phosphorylates ctni at thr(31), thr(51), thr(129) and thr(143). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182057 |
Thr31 |
SNYRAYAtEPHAKKK |
Homo sapiens |
|
| pmid |
sentence |
| 18986304 |
Ms analysis indicated that mst1 phosphorylates ctni at thr(31), thr(51), thr(129) and thr(143). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182061 |
Thr51 |
SRKLQLKtLLLQIAK |
Homo sapiens |
|
| pmid |
sentence |
| 18986304 |
Ms analysis indicated that mst1 phosphorylates ctni at thr(31), thr(51), thr(129) and thr(143). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
STK4 | down-regulates activity
phosphorylation
|
PRDX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276486 |
Thr18 |
PAPNFKAtAVMPDGQ |
in vitro |
|
| pmid |
sentence |
| 23386615 |
Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.Prdx1 is phosphorylated by Mst1 predominantly at Thr-18, Thr-90, and Thr-183. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276485 |
Thr183 |
GWKPGSDtIKPDVQK |
in vitro |
|
| pmid |
sentence |
| 23386615 |
Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.Prdx1 is phosphorylated by Mst1 predominantly at Thr-18, Thr-90, and Thr-183. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276487 |
Thr90 |
CHLAWVNtPKKQGGL |
in vitro |
|
| pmid |
sentence |
| 23386615 |
Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells.Prdx1 is phosphorylated by Mst1 predominantly at Thr-18, Thr-90, and Thr-183. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
MST1 | up-regulates
phosphorylation
|
STK4 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114289 |
Thr183 |
DTMAKRNtVIGTPFW |
Homo sapiens |
|
| pmid |
sentence |
| 11805089 |
We directly show that okadaic acid induces phosphorylation in the activation loop of mst, and, once phosphorylated, mst is rapidly translocated to the nucleus. when thr183 in mst1 was mutated to ala, no band could be detected by oa treatment,2 indicating that thr183 was the site of phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates
dephosphorylation
|
STK4 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201270 |
Thr183 |
DTMAKRNtVIGTPFW |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Rassf1a apparently protects mst1/2 against inactivation by pp2a , the phosphatases that dephosphorylate the stimulatory thr-183 and thr-180 of mst1 andmst2, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT3 | down-regulates
phosphorylation
|
STK4 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201129 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Full activation of mst1 requires an activation cleavage that is prevented by the phosphorylation of thr-387 by akt. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | up-regulates activity
dephosphorylation
|
STK4 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248329 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 20513427 |
PHLPPs dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates
phosphorylation
|
STK4 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201125 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Full activation of mst1 requires an activation cleavage that is prevented by the phosphorylation of thr-387 by akt. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP2 | up-regulates activity
dephosphorylation
|
STK4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248730 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 20513427 |
PHLPPs dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | down-regulates
phosphorylation
|
ABL1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181060 |
Thr735 |
DTEWRSVtLPRDLQS |
Homo sapiens |
|
| pmid |
sentence |
| 18794806 |
Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates activity
phosphorylation
|
STK4 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260927 |
Tyr433 |
KIPQDGDyEFLKSWT |
Rattus norvegicus |
|
| pmid |
sentence |
| 21715626 |
In the present study, we demonstrate that the protein kinase c-Abl phosphorylates MST1 at Y433, which triggers the stabilization and activation of MST1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
STK4 | up-regulates
phosphorylation
|
LATS1/2 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
SAV1 | up-regulates
binding
|
STK4 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
RAF1 | down-regulates
binding
|
STK4 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22898666 |
Raf1 binding to mst2 sarah domain interdicts mst2 homodimerization and autoactivation, and recruits protein phosphates 2a thereby promoting mst2 inactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
FOXO4 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK3 | up-regulates
phosphorylation
|
STK4 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK1 | up-regulates
phosphorylation
|
STK4 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
phosphorylation
|
Mob1 |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
okadaic acid | up-regulates 
|
STK4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23493077 |
Okadaic acid has been frequently used to enhance the phosphorylation of mst1 and mst2 and to trigger the activation of the hippo pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWC1 | up-regulates activity
|
STK4 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261954 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
SAV1 | up-regulates quantity by stabilization
binding
|
STK4 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16930133 |
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
RASSF1 | up-regulates
binding
|
STK4 |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
Rassf1a and mst1 co-exist as a complex localizing at microtubules throughout the cell cycle, of which the rassf1a mst1 interaction is stimulatory to the mst1 kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mst1/2 is also activated by binding to Ras association domain family (RASSF) proteins, possibly owing to alteration of Mst1/2 subcellular localization. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PHLPP1 | up-regulates
binding
|
STK4 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Here, we report that phlpp1 is a binding protein for mst1 and it modulates the hippo pathway by dephosphorylating mst1 at the inhibitory thr(387) of mst1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK4 | up-regulates
|
SAV1 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217833 |
|
|
in vitro |
|
| pmid |
sentence |
| 16930133 |
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Hippo Signaling |
| + |
TAOK | up-regulates
phosphorylation
|
STK4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230710 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
NF2 | up-regulates activity
binding
|
STK4 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261956 |
|
|
Mus musculus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 27402866 |
NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
STK4 | down-regulates 
|
AR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151712 |
|
|
|
|
| pmid |
sentence |
| 21512132 |
Mst1 plays a critical role in the regulation of programmed cell death and it has been implicated in PCa development. Interestingly, MST1 has been detected in AR-chromatin complexes, and forced expression of MST1 reduces AR binding to androgen-responsive elements along the PSA promoter. |
|
| Publications: |
1 |
| + |
Cell-Cell_contact | up-regulates
|
STK4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230693 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
In response to growth inhibitory signal (e.g. cellcell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
TAOK2 | up-regulates
phosphorylation
|
STK4 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok1 3 has been shown to directly phosphorylate and activate hpo or mst1/2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STK4
- 
- 