Summary

Name TERF2
Full Name Telomeric repeat-binding factor 2
Synonyms TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein | TRBF2, TRF2
Primary ID Q15554
Links - -
Type protein
Relations 5
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres

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Relations

Regulator Mechanism target score ℹ
+ HNRNPH1down-regulates quantity img/direct_inhibition.png post transcriptional regulation TERF2 0.346
Publications: 1 Organism: Rattus Norvegicus
+ TERF2down-regulates img/indirect_inhibition.png Neurogenesis 0.7
Publications: 1 Organism: Rattus Norvegicus
+ TERF2form complex img/form-complex.png binding Shelterin complex 0.798
Publications: 1 Organism: Homo Sapiens
+ HNRNPH2down-regulates quantity img/direct_inhibition.png post transcriptional regulation TERF2 0.344
Publications: 1 Organism: Rattus Norvegicus
+ TERF2down-regulates activity img/direct_inhibition.png binding ATM 0.672
Publications: 1