Summary

Name TAF1C
Full Name TATA box-binding protein-associated factor RNA polymerase I subunit C
Synonyms RNA polymerase I-specific TBP-associated factor 110 kDa, TAFI110, TATA box-binding protein-associated factor 1C, TBP-associated factor 1C, Transcription initiation factor SL1/TIF-IB subunit C |
Primary ID Q15572
Links - -
Type protein
Relations 2
Function Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding SL1 complex 0.797
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation TAF1C 0.2
Publications: 1 Organism: Homo Sapiens