Summary

Name TRIP11
Full Name Thyroid receptor-interacting protein 11
Synonyms TR-interacting protein 11, TRIP-11, Clonal evolution-related gene on chromosome 14 protein, Golgi-associated microtubule-binding protein 210, GMAP-210, Trip230 | CEV14
Primary ID Q15643
Links - -
Type protein
Relations 7
Function Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.

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Relations

Regulator Mechanism target score ℹ
+ TRIP11up-regulates activity img/direct-activation.png binding THR 0.422
Publications: 1 Organism: Homo Sapiens
+ RB1down-regulates img/direct_inhibition.png binding TRIP11 0.324
Publications: 1 Organism: Homo Sapiens
+ TRIP11up-regulates img/direct-activation.png binding THRA 0.387
Publications: 1 Organism: Homo Sapiens
+ TRIP11up-regulates img/direct-activation.png binding THR 0.422
Publications: 2 Organism: Homo Sapiens
+ TRIP11up-regulates img/direct-activation.png binding THRB 0.316
Publications: 1 Organism: Homo Sapiens
+ RAB2Aup-regulates activity img/direct-activation.png binding TRIP11 0.396
Publications: 1 Organism: Homo Sapiens