3.0
Summary
| Name |  SNCBView Modifications |
| Full Name | Beta-synuclein |
| Synonyms | SYUB_HUMAN |
| Primary ID | Q16143 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GRK5 | down-regulates activity 
phosphorylation
|
SNCB | 0.326 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PLK1 | down-regulates activity
phosphorylation
|
SNCB | 0.323 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK2 | down-regulates activity
phosphorylation
|
SNCB | 0.251 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK3 | down-regulates activity
phosphorylation
|
SNCB | 0.389 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHEK1 |
phosphorylation
|
SNCB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |