| + |
PLK2 | down-regulates activity 
phosphorylation
|
SNCB |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189049 |
Ser118 |
LMEPEGEsYEDPPQE |
Homo sapiens |
|
| pmid |
sentence |
| 19889641 |
Polo-like kinase (plk) family (plk1, plk2, and plk3) phosphorylate alpha-syn and beta-syn specifically at ser-129 and ser-118, respectively. Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type -synuclein, was increased by serine 129 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | down-regulates activity
phosphorylation
|
SNCA |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182155 |
Ser129 |
NEAYEMPsEEGYQDY |
Homo sapiens |
|
| pmid |
sentence |
| 19889641 |
Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type -synuclein, was increased by serine 129 phosphorylation. Pathological serine 129 phosphorylation regulates membrane accumulation of mutant alpha-synuclein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | down-regulates
phosphorylation
|
FBXW7 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196448 |
Ser176 |
KRKLDHGsEVRSFSL |
Homo sapiens |
|
| pmid |
sentence |
| 22399798 |
Plk2 regulates centriole duplication through phosphorylation-mediated degradation of fbxw7 (human cdc4).Plk2 phosphorylates fbxw7 on serine 176 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | up-regulates quantity by stabilization 
phosphorylation
|
PLK2 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277805 |
Ser358 |
VPDFHLSsPAKNFFK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 37387444 |
In the present study, it was demonstrated that dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) interacts with and phosphorylates PLK2 at Ser358. DYRK1A-mediated phosphorylation of PLK2 increases its protein stability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277791 |
Ser358 |
VPDFHLSsPAKNFFK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 37387444 |
In the present study, it was demonstrated that dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) interacts with and phosphorylates PLK2 at Ser358. DYRK1A-mediated phosphorylation of PLK2 increases its protein stability. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK2 | up-regulates
phosphorylation
|
NPM1 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125720 |
Ser4 |
sMDMDMSP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15190079 |
Phosphorylated at ser-4 by plk1 and plk2. Phosphorylation at ser-4 by plk2 in s phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at ser-4 by plk1 takes place during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | down-regulates activity
phosphorylation
|
TP73 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278218 |
Ser48 |
VVGGTDSsMDVFHLE |
Homo sapiens |
|
| pmid |
sentence |
| 26625870 |
PLK2 inhibits TAp73 translocation to the nucleus.|PLK2 phosphorylated TAp73 at residue Ser48 within the TA domain; phosphorylation of TAp73 was abolished by mutating this residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | up-regulates
phosphorylation
|
CENPJ |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165999 |
Ser589 |
EQAADEIsFSSNSSF |
Homo sapiens |
|
| pmid |
sentence |
| 20531387 |
Plk2 phosphorylates the s589 and s595 residues of cpap in vitro and in vivo. This phosphorylation is critical for procentriole formation during the centrosome cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166003 |
Ser595 |
ISFSSNSsFVLKILE |
Homo sapiens |
|
| pmid |
sentence |
| 20531387 |
Plk2 phosphorylates the s589 and s595 residues of cpap in vitro and in vivo. This phosphorylation is critical for procentriole formation during the centrosome cycle. Plk4 also phosphorylates s595 of cpap |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK2 | up-regulates activity
phosphorylation
|
APP |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279424 |
Thr743 |
VEVDAAVtPEERHLS |
Homo sapiens |
|
| pmid |
sentence |
| 28257888 |
Here we show that Polo-like kinase 2 (Plk2), an activity-inducible regulator of homeostatic plasticity, directly binds and phosphorylates threonine-668 and serine-675 of APP in\u00a0vitro and associates with APP in\u00a0vivo.|Plk2 was necessary and sufficient to induce BACE-1-mediated APP amyloidogenic processing following overexcitation, associated intimately with APP, and directly phosphorylated the APP C-terminus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | up-regulates activity
phosphorylation
|
LRPAP1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279476 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21382555 |
Inhibition of Ras and activation of Rap by Plk2.|Plk2 phosphorylation of Ras and Rap regulators controls surface AMPARs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VPS18 | down-regulates quantity by destabilization
ubiquitination
|
PLK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271550 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16203730 |
VPS18 Ubiquitylates SNK in Vitro and in Vivo. The ubiquitylation of proteins by hVPS18 was selectively mediated by UbcH4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | up-regulates activity
phosphorylation
|
TP53 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29448085 |
Other investigators have demonstrated that Plk2 phosphorylates mutant p53 in a positive feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLK2
- 
- 