| + |
SEPTIN7 | up-regulates activity 
binding
|
CENPE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252040 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18460473 |
These findings reveal a key role for the SEPT7-CENP-E interaction in the distribution of CENP-E to the kinetochore and achieving chromosome alignment. We propose that SEPT7 forms a link between kinetochore distribution of CENP-E and the mitotic spindle checkpoint. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AR | down-regulates quantity by repression 
transcriptional regulation
|
SEPTIN7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253677 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 16281084 |
After AR antagonist flutamide treatment, three hundred and twenty-six genes (3.93%) expressed differentially, 97 down-regulated and 219 up-regulated. Among them, eight up-regulated genes might be cell cycle-related, namely CDC10, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKN1A and BTG2. The CDKN1A and BTG1 gene mRNA expression was confirmed to be higher in the experimental group by RT-PCR, while p53 mRNA expression had no significant changes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SEPTIN7 | form complex 
binding
|
SEPT6/SEPT7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148898 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16914550 |
We have characterized the conformation of a complex of filamentous human septins, sept2, sept6, and sept7. / we now show that sept6 and sept7 interact through a parallel coiled-coil, and that sept2 interacts with sept6 through their c-terminal domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SEPTIN7
- 
- 