| + |
CENPE | up-regulates 
|
Spindle_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252013 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
PRC1 | up-regulates activity 
binding
|
CENPE |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265990 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15297875 |
These data indicate that PRC1 binds to KIF4, MKLP1 and CENP-E during late mitosis; however, it apparently does not interact simultaneously with more than one of these motor proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CENPE | up-regulates activity
binding
|
BUB1B |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252043 |
|
|
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 12925705 |
Without CENP-E, diminished levels of BubR1 are recruited to kinetochores and BubR1 kinase activity remains at basal levels. CENP-E binds to and directly stimulates the kinase activity of purified BubR1 in vitro. Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266118 |
|
|
in vitro |
|
| pmid |
sentence |
| 12925705 |
CENP-E binds to and directly stimulates the kinase activity of purified BubR1 in vitro. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, In Vitro |
| + |
CDR2 | up-regulates quantity by expression
transcriptional regulation
|
CENPE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252020 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
BUB1 | up-regulates activity
relocalization
|
CENPE |
0.824 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252016 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
SEPTIN7 | up-regulates activity
binding
|
CENPE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252040 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18460473 |
These findings reveal a key role for the SEPT7-CENP-E interaction in the distribution of CENP-E to the kinetochore and achieving chromosome alignment. We propose that SEPT7 forms a link between kinetochore distribution of CENP-E and the mitotic spindle checkpoint. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA3 | up-regulates activity
|
CENPE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252037 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20383198 |
We also show that this kinase might also participate in the maintenance of the SAC in mammalian cells as Rsk2 knockdown in these cells prevents the kinetochore localization of Mad1, Mad2 and CENP-E under checkpoint conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CENPE | up-regulates activity
|
MAD2L1 |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252045 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12925705 |
CENP-E is required for efficient recruitment of BubR1, Mad1, and Mad2 to attached and newly unattached kinetochores |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CENPE | up-regulates activity
|
MAD1L1 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252044 |
|
|
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 12925705 |
CENP-E is required for efficient recruitment of BubR1, Mad1, and Mad2 to attached and newly unattached kinetochores |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SPAG5 | up-regulates activity
|
CENPE |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252041 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17664331 |
Furthermore, although both the core kinetochore protein Hec1 and the spindle checkpoint kinase Bub1 were unaffected (Fig. 3 C), the kinetochore resident motor protein CENP-E (Yen et al., 1992) and its interaction partner CENP-F (Chan et al., 1998) were delocalized from the kinetochore in the absence of astrin. These cells remained cyclin B1 positive (unpublished data), confirming that they were still in mitosis. These data suggest that the presence of astrin is required for the kinetochore recruitment or maintenance of CENP-E and CENP-F. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIFC1 | up-regulates activity
binding
|
CENPE |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266116 |
|
|
Homo sapiens |
SKOV-3 Cell |
| pmid |
sentence |
| 33361741 |
We found that KIFC1 could directly bind to CENPE in SKOV3 cells (Figure 4C, 4D). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CENPE
- 
- 